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• W2034288843 abstract "Renal cell carcinoma (RCC) is a prototype of a chemorefractory tumor. It remains the most lethal of the common urologic cancers, with approximately 40% of patients eventually dying of disease progression. 1 Janzen N.K. Kim H.L. Figlin R.A. et al. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003; 30: 843-852 Abstract Full Text Full Text PDF PubMed Scopus (644) Google Scholar Surgical treatment is curative for localized disease, yet 25% of patients present with locally advanced or disseminated disease and 20% to 30% of patients with localized disease at presentation will develop systemic recurrence. 1 Janzen N.K. Kim H.L. Figlin R.A. et al. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003; 30: 843-852 Abstract Full Text Full Text PDF PubMed Scopus (644) Google Scholar Few patients respond to interleukin-2 or interferon (IFN)-based immunotherapy, and these treatments can be associated with considerable toxicity. 2 Coppin C. Porzsolt F. Awa A. et al. Immunotherapy for advanced renal cell cancer. Cochrane Database Syst Rev CD001425. 2005; Google Scholar However, the incidence of advanced RCC is increasing by 2% to 3% annually, similar to localized RCC, and this malignancy was responsible for 12,000 cancer-related deaths in the United States in 2005. 3 Chow W.H. Devesa S.S. Warren J.L. et al. Rising incidence of renal cell cancer in the united states. JAMA. 1999; 281: 1628-1631 Crossref PubMed Scopus (1357) Google Scholar" @default.
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• W2034288843 date "2007-01-01" @default.
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• W2034288843 title "Targeted Molecular Therapy for Renal Cell Carcinoma" @default.
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• W2034288843 doi "https://doi.org/10.1016/j.urology.2006.09.028" @default.
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