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- W2034291006 abstract "Abstract Glibenclamide, glipizide and phentolamine, three drugs which have been reported to block ATP-dependent potassium channels, increased the coronary perfusion pressure in guinea-pig isolated hearts perfused at constant flow. Blockers of other types of potassium channels, 4-aminopyridine and UK-66,914, did not significantly increase perfusion pressure. Exposing hearts to a single concentration of 3 μm glibenclamide caused a greater degree of vasoconstriction than when this was preceded by lower concentrations. The 3 μm glibenclamide-induced vasoconstriction was reduced by prazosin(1 μm), mepyramine(0·1 μm) and ranitidine (10 μm) but not by a combination of mepyramine and ranitidine or by ritanserin (001 μm). These results suggest that a component of the vasoconstriction induced by glibenclamide may result indirectly from the release of vasoactive mediators." @default.
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- W2034291006 date "1993-07-01" @default.
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- W2034291006 title "K+ -Channel blockers and coronary vasoconstriction in guinea-pig perfused hearts in-vitro" @default.
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- W2034291006 doi "https://doi.org/10.1111/j.2042-7158.1993.tb05677.x" @default.
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