FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034291567> ?p ?o ?g. }

• W2034291567 endingPage "40432" @default.
• W2034291567 startingPage "40425" @default.
• W2034291567 abstract "Halogenated inhaled anesthetics modulate voltage-gated ion channels by unknown mechanisms.Biophysical analyses revealed novel activation of K(v) channels by the inhaled anesthetic sevoflurane.K(v) channel activation by sevoflurane results from the positive allosteric modulation of activation gating.The unique activation of K(v) channels by sevoflurane demonstrates novel anesthetic specificity and offers new insights into allosteric modulation of channel gating. Voltage-gated ion channels are modulated by halogenated inhaled general anesthetics, but the underlying molecular mechanisms are not understood. Alkanols and halogenated inhaled anesthetics such as halothane and isoflurane inhibit the archetypical voltage-gated Kv3 channel homolog K-Shaw2 by stabilizing the resting/closed states. By contrast, sevoflurane, a more heavily fluorinated ether commonly used in general anesthesia, specifically activates K-Shaw2 currents at relevant concentrations (0.05-1 mM) in a rapid and reversible manner. The concentration dependence of this modulation is consistent with the presence of high and low affinity interactions (K(D) = 0.06 and 4 mM, respectively). Sevoflurane (<1 mM) induces a negative shift in the conductance-voltage relation and increases the maximum conductance. Furthermore, suggesting possible roles in general anesthesia, mammalian Kv1.2 and Kv1.5 channels display similar changes. Quantitative description of the observations by an economical allosteric model indicates that sevoflurane binding favors activation gating and eliminates an unstable inactivated state outside the activation pathway. This study casts light on the mechanism of the novel sevoflurane-dependent activation of Kv channels, which helps explain how closely related inhaled anesthetics achieve specific actions and suggests strategies to develop novel Kv channel activators." @default.
• W2034291567 created "2016-06-24" @default.
• W2034291567 creator A5001832224 @default.
• W2034291567 creator A5053813835 @default.
• W2034291567 creator A5077364060 @default.
• W2034291567 date "2012-11-01" @default.
• W2034291567 modified "2023-09-26" @default.
• W2034291567 title "Novel Activation of Voltage-gated K+ Channels by Sevoflurane" @default.
• W2034291567 cites W127764071 @default.
• W2034291567 cites W1536217954 @default.
• W2034291567 cites W1537202898 @default.
• W2034291567 cites W1541419413 @default.
• W2034291567 cites W1600620818 @default.
• W2034291567 cites W1931208730 @default.
• W2034291567 cites W1946447667 @default.
• W2034291567 cites W1977193321 @default.
• W2034291567 cites W1978348024 @default.
• W2034291567 cites W1983565109 @default.
• W2034291567 cites W1983915711 @default.
• W2034291567 cites W1992450814 @default.
• W2034291567 cites W1999423218 @default.
• W2034291567 cites W2002066071 @default.
• W2034291567 cites W2013464874 @default.
• W2034291567 cites W2013546235 @default.
• W2034291567 cites W2016371604 @default.
• W2034291567 cites W2017183797 @default.
• W2034291567 cites W2017573186 @default.
• W2034291567 cites W2017981180 @default.
• W2034291567 cites W2037471264 @default.
• W2034291567 cites W2046357793 @default.
• W2034291567 cites W2048900556 @default.
• W2034291567 cites W2054310238 @default.
• W2034291567 cites W2072366454 @default.
• W2034291567 cites W2074957858 @default.
• W2034291567 cites W2078037173 @default.
• W2034291567 cites W2082372069 @default.
• W2034291567 cites W2088909919 @default.
• W2034291567 cites W2089367180 @default.
• W2034291567 cites W2104389482 @default.
• W2034291567 cites W2104759180 @default.
• W2034291567 cites W2112141608 @default.
• W2034291567 cites W2115769413 @default.
• W2034291567 cites W2121707070 @default.
• W2034291567 cites W2123683153 @default.
• W2034291567 cites W2134725139 @default.
• W2034291567 cites W2137002627 @default.
• W2034291567 cites W2147126631 @default.
• W2034291567 cites W2154086558 @default.
• W2034291567 cites W2157618404 @default.
• W2034291567 cites W2169478814 @default.
• W2034291567 doi "https://doi.org/10.1074/jbc.m112.405787" @default.
• W2034291567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3504757" @default.
• W2034291567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23038249" @default.
• W2034291567 hasPublicationYear "2012" @default.
• W2034291567 type Work @default.
• W2034291567 sameAs 2034291567 @default.
• W2034291567 citedByCount "35" @default.
• W2034291567 countsByYear W20342915672013 @default.
• W2034291567 countsByYear W20342915672014 @default.
• W2034291567 countsByYear W20342915672015 @default.
• W2034291567 countsByYear W20342915672016 @default.
• W2034291567 countsByYear W20342915672017 @default.
• W2034291567 countsByYear W20342915672018 @default.
• W2034291567 countsByYear W20342915672019 @default.
• W2034291567 countsByYear W20342915672020 @default.
• W2034291567 countsByYear W20342915672021 @default.
• W2034291567 countsByYear W20342915672022 @default.
• W2034291567 countsByYear W20342915672023 @default.
• W2034291567 crossrefType "journal-article" @default.
• W2034291567 hasAuthorship W2034291567A5001832224 @default.
• W2034291567 hasAuthorship W2034291567A5053813835 @default.
• W2034291567 hasAuthorship W2034291567A5077364060 @default.
• W2034291567 hasBestOaLocation W20342915671 @default.
• W2034291567 hasConcept C114614502 @default.
• W2034291567 hasConcept C121932024 @default.
• W2034291567 hasConcept C12554922 @default.
• W2034291567 hasConcept C166342909 @default.
• W2034291567 hasConcept C170493617 @default.
• W2034291567 hasConcept C178790620 @default.
• W2034291567 hasConcept C185592680 @default.
• W2034291567 hasConcept C194544171 @default.
• W2034291567 hasConcept C2776359302 @default.
• W2034291567 hasConcept C2776932660 @default.
• W2034291567 hasConcept C2778162923 @default.
• W2034291567 hasConcept C2781453256 @default.
• W2034291567 hasConcept C33923547 @default.
• W2034291567 hasConcept C37088560 @default.
• W2034291567 hasConcept C42219234 @default.
• W2034291567 hasConcept C50254741 @default.
• W2034291567 hasConcept C55493867 @default.
• W2034291567 hasConcept C71924100 @default.
• W2034291567 hasConcept C83743174 @default.
• W2034291567 hasConcept C86803240 @default.
• W2034291567 hasConceptScore W2034291567C114614502 @default.
• W2034291567 hasConceptScore W2034291567C121932024 @default.
• W2034291567 hasConceptScore W2034291567C12554922 @default.
• W2034291567 hasConceptScore W2034291567C166342909 @default.
• W2034291567 hasConceptScore W2034291567C170493617 @default.

• next