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- W2034292275 abstract "A survey was undertaken to define the infectious problems which occurred during intensive treatment of acute myeloblastic leukaemia. Two-hundred patients, treated consecutively at a single hospital, were studied. Bacteraemia, pneumonia and wound infecions were the most common infectious problems; the most important bacterial pathogens were Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The presence of severe neutropenia and/or falling granulocyte count were accompanied by a worse prognosis. Patients who had a temperature of at least 38°C at initial presentation had a significantly worse complete remission (CR) rate (P < 0.015) and survival rate (P < 0.01) than patients who were afebrile; this difference could not be explained by more frequent early death in the febrile group. Presence of fever at diagnosis, like age and platelet count, is thus an important prognostic factor. A scoring system, based on these diagnostic features, should help to identify those patients who, because of high probability of entering CR, should be aggressively treated. Conversely, the outlook for non-responding patients may be improved by the delivery of less intensive chemotherapy when probability of entering CR, based on criteria available within hours of admission, is very low." @default.
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- W2034292275 date "1978-04-01" @default.
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- W2034292275 title "Bacterial infection and acute myeloblastic leukaemia: An analysis of two hundred patients undergoing intensive remission induction therapy" @default.
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- W2034292275 doi "https://doi.org/10.1016/0014-2964(78)90209-8" @default.
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