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- W2034292553 abstract "Transforming growth factor-α (TGF-α) is a 50-amino acid polypeptide synthesized as part of a larger precursor of 159 amino acids. Its expression has been reported in normal and neoplastic kidney. In this report, we characterized a renal TGF-α-immunoreactive protein, which we named TGF-α-related protein (TGF-α-RP). It was found to be present in the final part of the collecting tubules of the normal rat kidney. Western blotting analysis of kidney samples revealed a protein of 38 kD and pI = 5.5. In nonreducing conditions immunoreaction for this protein decreased and a TGF-α-immunoreactive protein of 150 kD was observed. The expression of TGF-α-RP seems to be highly conserved in the kidney of mammals and chickens. Therefore, TGF-α-RP may have an important role in the normal development and function of the kidney." @default.
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- W2034292553 date "1999-01-01" @default.
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- W2034292553 title "Immunochemical Localization of Transforming Growth Factor-α-Related Protein in the Rat Kidney" @default.
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- W2034292553 doi "https://doi.org/10.1159/000045300" @default.
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