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• W2034294534 abstract "Abstract Although apolipoprotein E (ApoE) polymorphism is associated with variable risks of several illnesses, and with mortality, no persuasive relationship has been demonstrated with frailty. Here, the clinical examination cohort ( n = 1452 older adults, aged 70+ years at baseline) of the Canadian Study of Health and Aging was evaluated, with 5‐year follow‐up data. Frailty was defined using both the phenotypic definition from the Cardiovascular Health Study (Frailty‐CHS) and the ‘Frailty Index’, from which age‐specific trajectories of deficit accumulation can be estimated. In age‐sex adjusted analyses, people with ApoE 4 allele had a higher risk of death (hazard ratio [HR]= 1.20; 95% confidence interval: 1.01–1.45), but this relationship was not significant when adjusted for cognitive impairment (1.06; 95% confidence interval: 0.88–1.27). There was no association between frailty and ApoE polymorphism, defined in age‐sex adjusted models either as Frailty‐CHS (ApoE4 HR 1.17; 95% confidence interval: 0.98–1.40, frailty HR 1.37; 95% confidence interval: 1.28–1.46) or by the Frailty Index (ApoE4 HR 1.07; 95% confidence interval: 0.90–1.29, frailty HR 35.3; 95% confidence interval: 20.4–61.1). The data do not support an association between ApoE polymorphism and frailty. This result did not depend on how frailty was defined." @default.
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• W2034294534 date "2008-12-02" @default.
• W2034294534 modified "2023-10-16" @default.
• W2034294534 title "Apolipoprotein E-polymorphism, frailty and mortality in older adults" @default.
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• W2034294534 doi "https://doi.org/10.1111/j.1582-4934.2008.00270.x" @default.
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