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• W2034294605 abstract "Liver regeneration is known to occur in mice lacking one or more Toll-like receptors (TLRs) or the adaptor protein MyD88. Though MyD88 is required for signaling by many TLRs, others signal via MyD88-independent pathways, leading to the induction of type I interferons (IFNs). Here, we assessed liver regeneration after partial hepatectomy (PH) in mice lacking both MyD88 and the type I IFN receptor ( Myd88-IFNAR double-KO). Approximately 28% of Myd88-IFNAR double-KO mice had gross liver lesions prior to surgery. In mice without lesions, Myd88-IFNAR deficiency abrogated the increase in circulating IL-6 after PH but did not impair hepatocyte BrdU incorporation, mitotic figure counts, or recovery of liver-to-body weight ratios. These results indicate that type I IFNs are not responsible for the preservation of liver regeneration in Myd88 -deficient mice, and they also cast doubt on the idea of microbial products being essential triggers of liver regeneration in mice undergoing PH." @default.
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• W2034294605 date "2011-01-01" @default.
• W2034294605 modified "2023-10-15" @default.
• W2034294605 title "Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency ofMyd88andIFNARGenes" @default.
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• W2034294605 doi "https://doi.org/10.1155/2011/727403" @default.
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