FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034294648> ?p ?o ?g. }

• W2034294648 endingPage "55" @default.
• W2034294648 startingPage "48" @default.
• W2034294648 abstract "The cachexia-anorexia syndrome, in which patients suffering from chronic illness lack the desire to eat and experience weight loss, creates a serious clinical problem when patients are attempting to overcome the disease process. Endotoxin (ET) has many actions in the brain and peripheral injections can affect regulation of monoamines in brain areas as diverse as the olfactory lobes and the locus coeruleus. Certainly, ET is involved in the febrile process and it plays a prominent role in the regulation of food intake and maintenance of body weight during chronic illnesses. Monoamine neurotransmitters in specific regions of the hypothalamus also participate in the regulation of food intake and body weight and have been well characterized. In this regard, the hypothalamic perifornical nucleus (PFN) is of interest to our lab due to its role in drug-induced anorexia caused by amphetamines. It is also the most sensitive site in the hypothalamic monoaminergic system that involves dopamine (DA) and epinephrine (EPI). DA antagonist, stereotaxically placed in this site, can stimulate feeding, and specific injections of DA or EPI can result in a 70–90% decrease in food intake, even in food-deprived animals. We have shown in our studies that ET in a dose (0.2 mg/kg of lipopolysaccharide) that does not induce noticeable ambulatory (lack of movement) effects (related to malaise) can cause a significant decrease in food intake in lean Zucker rats. We hypothesize that exogenous ET causes an increase in the extracellular concentrations of monoamines in the perifornical hypothalamus, which in turn can mediate the decrease in food intake. Microdialysis was utilized to measure extracellular concentrations of EPI, norepinephrine, 5-hydroxyindoleacetic acid, DA, and serotonin or 5-hydroxytryptamine. These measurements were taken at a post-ET time period that coincides with an ET-induced decrease (4×) in food intake. Extracellular DA and EPI both significantly increased in the PFN in response to injection of ET. Increases in extracellular DA were dose related and were significant (p < 0.05) compared to zero baseline and saline at both doses of ET. No statistically significant differences were found in 5-hydroxyindoleacetic acid, norepinephrine, and serotonin in microdialysates of this part of the hypothalamus. The present data suggest that catecholamines, namely DA and EPI which are known to decrease food intake, in the PFN may be involved in the regulation of decreases in food intake caused by peripherally administered ET. This does not rule out a role for locally produced inflammatory molecules in the brain in this process." @default.
• W2034294648 created "2016-06-24" @default.
• W2034294648 creator A5008889450 @default.
• W2034294648 creator A5040670098 @default.
• W2034294648 creator A5051927996 @default.
• W2034294648 creator A5061598534 @default.
• W2034294648 date "2009-11-26" @default.
• W2034294648 modified "2023-09-26" @default.
• W2034294648 title "Role of the Perifornical Hypothalamic Monoamine Neurotransmitter Systems in Anorectic Effects of Endotoxin" @default.
• W2034294648 cites W120080490 @default.
• W2034294648 cites W1590186584 @default.
• W2034294648 cites W1796891966 @default.
• W2034294648 cites W1965589496 @default.
• W2034294648 cites W1970047401 @default.
• W2034294648 cites W1973852095 @default.
• W2034294648 cites W1976447692 @default.
• W2034294648 cites W1982482743 @default.
• W2034294648 cites W1986012426 @default.
• W2034294648 cites W1986949319 @default.
• W2034294648 cites W2000269824 @default.
• W2034294648 cites W2018219903 @default.
• W2034294648 cites W2051329667 @default.
• W2034294648 cites W2055711680 @default.
• W2034294648 cites W2059819618 @default.
• W2034294648 cites W2063508561 @default.
• W2034294648 cites W2066705445 @default.
• W2034294648 cites W2069110605 @default.
• W2034294648 cites W2086542452 @default.
• W2034294648 cites W2108012102 @default.
• W2034294648 cites W2119898157 @default.
• W2034294648 cites W2121594859 @default.
• W2034294648 cites W2133152748 @default.
• W2034294648 cites W2145928544 @default.
• W2034294648 cites W2148256905 @default.
• W2034294648 cites W2150833441 @default.
• W2034294648 cites W2151559815 @default.
• W2034294648 cites W2163815564 @default.
• W2034294648 cites W2182736412 @default.
• W2034294648 cites W2299544063 @default.
• W2034294648 cites W2394600779 @default.
• W2034294648 cites W2403952277 @default.
• W2034294648 cites W30854762 @default.
• W2034294648 doi "https://doi.org/10.1159/000262446" @default.
• W2034294648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19940463" @default.
• W2034294648 hasPublicationYear "2009" @default.
• W2034294648 type Work @default.
• W2034294648 sameAs 2034294648 @default.
• W2034294648 citedByCount "6" @default.
• W2034294648 countsByYear W20342946482012 @default.
• W2034294648 countsByYear W20342946482013 @default.
• W2034294648 countsByYear W20342946482023 @default.
• W2034294648 crossrefType "journal-article" @default.
• W2034294648 hasAuthorship W2034294648A5008889450 @default.
• W2034294648 hasAuthorship W2034294648A5040670098 @default.
• W2034294648 hasAuthorship W2034294648A5051927996 @default.
• W2034294648 hasAuthorship W2034294648A5061598534 @default.
• W2034294648 hasConcept C126322002 @default.
• W2034294648 hasConcept C134018914 @default.
• W2034294648 hasConcept C15744967 @default.
• W2034294648 hasConcept C169760540 @default.
• W2034294648 hasConcept C170493617 @default.
• W2034294648 hasConcept C187714386 @default.
• W2034294648 hasConcept C2775864247 @default.
• W2034294648 hasConcept C2776219046 @default.
• W2034294648 hasConcept C2777003273 @default.
• W2034294648 hasConcept C2777369949 @default.
• W2034294648 hasConcept C2778468602 @default.
• W2034294648 hasConcept C2778514916 @default.
• W2034294648 hasConcept C2778654693 @default.
• W2034294648 hasConcept C2780714764 @default.
• W2034294648 hasConcept C3018685816 @default.
• W2034294648 hasConcept C42251903 @default.
• W2034294648 hasConcept C513476851 @default.
• W2034294648 hasConcept C529278444 @default.
• W2034294648 hasConcept C71924100 @default.
• W2034294648 hasConceptScore W2034294648C126322002 @default.
• W2034294648 hasConceptScore W2034294648C134018914 @default.
• W2034294648 hasConceptScore W2034294648C15744967 @default.
• W2034294648 hasConceptScore W2034294648C169760540 @default.
• W2034294648 hasConceptScore W2034294648C170493617 @default.
• W2034294648 hasConceptScore W2034294648C187714386 @default.
• W2034294648 hasConceptScore W2034294648C2775864247 @default.
• W2034294648 hasConceptScore W2034294648C2776219046 @default.
• W2034294648 hasConceptScore W2034294648C2777003273 @default.
• W2034294648 hasConceptScore W2034294648C2777369949 @default.
• W2034294648 hasConceptScore W2034294648C2778468602 @default.
• W2034294648 hasConceptScore W2034294648C2778514916 @default.
• W2034294648 hasConceptScore W2034294648C2778654693 @default.
• W2034294648 hasConceptScore W2034294648C2780714764 @default.
• W2034294648 hasConceptScore W2034294648C3018685816 @default.
• W2034294648 hasConceptScore W2034294648C42251903 @default.
• W2034294648 hasConceptScore W2034294648C513476851 @default.
• W2034294648 hasConceptScore W2034294648C529278444 @default.
• W2034294648 hasConceptScore W2034294648C71924100 @default.
• W2034294648 hasIssue "1" @default.
• W2034294648 hasLocation W20342946481 @default.
• W2034294648 hasLocation W20342946482 @default.
• W2034294648 hasOpenAccess W2034294648 @default.

• next