FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034294823> ?p ?o ?g. }

• W2034294823 endingPage "93" @default.
• W2034294823 startingPage "79" @default.
• W2034294823 abstract "Male rats with hypogonadism ( hgn/hgn ) experience sterility from testicular dysplasia, which is controlled by a single recessive gene, hgn. The postnatal growth of the seminiferous tubules was severely affected. In this study, we localized the hgn locus to a 320 kb region on rat chromosome 10 and detected the insertion of a 25 bp duplication into the sixth exon of the sperm-associated antigen 5 ( Spag 5/ astrin/MAP126 ) gene, which codes for a microtubule-associated protein. This mutation results in a truncated Spag5 protein lacking the primary spindle-targeting domain at the C terminus. Immunological staining with antibodies to markers for Sertoli and germ cells during the early postnatal period indicated that the abnormal mitosis with dispersed chromosomes in hgn/hgn testes occurs in proliferating Sertoli cells. Therefore, apoptotic Sertoli cell death would result from the disorganization of the spindle apparatus caused by defective Spag5 . These findings suggested that the Spag5 is essential for testis development in rats and that the hgn/hgn rat is a unique animal model for studying the function of Spag5 ." @default.
• W2034294823 created "2016-06-24" @default.
• W2034294823 creator A5014802983 @default.
• W2034294823 creator A5026841472 @default.
• W2034294823 creator A5046362015 @default.
• W2034294823 date "2006-07-01" @default.
• W2034294823 modified "2023-10-16" @default.
• W2034294823 title "Duplicated insertion mutation in the microtubule-associated protein Spag5 (astrin/MAP126) and defective proliferation of immature Sertoli cells in rat hypogonadic (hgn/hgn) testes" @default.
• W2034294823 cites W1969095926 @default.
• W2034294823 cites W1971133763 @default.
• W2034294823 cites W1976435237 @default.
• W2034294823 cites W1982229072 @default.
• W2034294823 cites W1987318152 @default.
• W2034294823 cites W1992748701 @default.
• W2034294823 cites W2007076357 @default.
• W2034294823 cites W2009170444 @default.
• W2034294823 cites W2019161059 @default.
• W2034294823 cites W2021066535 @default.
• W2034294823 cites W2021736637 @default.
• W2034294823 cites W2023359733 @default.
• W2034294823 cites W2025218658 @default.
• W2034294823 cites W2045259675 @default.
• W2034294823 cites W2052937796 @default.
• W2034294823 cites W2062128071 @default.
• W2034294823 cites W2073077880 @default.
• W2034294823 cites W2078017434 @default.
• W2034294823 cites W2079076800 @default.
• W2034294823 cites W2081675572 @default.
• W2034294823 cites W2087919149 @default.
• W2034294823 cites W2088286225 @default.
• W2034294823 cites W2094686661 @default.
• W2034294823 cites W2098737213 @default.
• W2034294823 cites W2121132919 @default.
• W2034294823 cites W2130119155 @default.
• W2034294823 cites W2156709043 @default.
• W2034294823 cites W2286357935 @default.
• W2034294823 cites W2316992263 @default.
• W2034294823 cites W2332034990 @default.
• W2034294823 cites W4254780104 @default.
• W2034294823 doi "https://doi.org/10.1530/rep.1.01104" @default.
• W2034294823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16816335" @default.
• W2034294823 hasPublicationYear "2006" @default.
• W2034294823 type Work @default.
• W2034294823 sameAs 2034294823 @default.
• W2034294823 citedByCount "20" @default.
• W2034294823 countsByYear W20342948232012 @default.
• W2034294823 countsByYear W20342948232014 @default.
• W2034294823 countsByYear W20342948232015 @default.
• W2034294823 countsByYear W20342948232016 @default.
• W2034294823 countsByYear W20342948232017 @default.
• W2034294823 countsByYear W20342948232019 @default.
• W2034294823 countsByYear W20342948232021 @default.
• W2034294823 countsByYear W20342948232022 @default.
• W2034294823 crossrefType "journal-article" @default.
• W2034294823 hasAuthorship W2034294823A5014802983 @default.
• W2034294823 hasAuthorship W2034294823A5026841472 @default.
• W2034294823 hasAuthorship W2034294823A5046362015 @default.
• W2034294823 hasBestOaLocation W20342948231 @default.
• W2034294823 hasConcept C104317684 @default.
• W2034294823 hasConcept C123765429 @default.
• W2034294823 hasConcept C126322002 @default.
• W2034294823 hasConcept C134018914 @default.
• W2034294823 hasConcept C153911025 @default.
• W2034294823 hasConcept C2779122487 @default.
• W2034294823 hasConcept C2781068068 @default.
• W2034294823 hasConcept C36823959 @default.
• W2034294823 hasConcept C54355233 @default.
• W2034294823 hasConcept C71924100 @default.
• W2034294823 hasConcept C86803240 @default.
• W2034294823 hasConcept C93304396 @default.
• W2034294823 hasConcept C95444343 @default.
• W2034294823 hasConceptScore W2034294823C104317684 @default.
• W2034294823 hasConceptScore W2034294823C123765429 @default.
• W2034294823 hasConceptScore W2034294823C126322002 @default.
• W2034294823 hasConceptScore W2034294823C134018914 @default.
• W2034294823 hasConceptScore W2034294823C153911025 @default.
• W2034294823 hasConceptScore W2034294823C2779122487 @default.
• W2034294823 hasConceptScore W2034294823C2781068068 @default.
• W2034294823 hasConceptScore W2034294823C36823959 @default.
• W2034294823 hasConceptScore W2034294823C54355233 @default.
• W2034294823 hasConceptScore W2034294823C71924100 @default.
• W2034294823 hasConceptScore W2034294823C86803240 @default.
• W2034294823 hasConceptScore W2034294823C93304396 @default.
• W2034294823 hasConceptScore W2034294823C95444343 @default.
• W2034294823 hasIssue "1" @default.
• W2034294823 hasLocation W20342948231 @default.
• W2034294823 hasLocation W20342948232 @default.
• W2034294823 hasOpenAccess W2034294823 @default.
• W2034294823 hasPrimaryLocation W20342948231 @default.
• W2034294823 hasRelatedWork W1967279915 @default.
• W2034294823 hasRelatedWork W1995616568 @default.
• W2034294823 hasRelatedWork W2078197242 @default.
• W2034294823 hasRelatedWork W2078753179 @default.
• W2034294823 hasRelatedWork W2160639260 @default.
• W2034294823 hasRelatedWork W2194405550 @default.
• W2034294823 hasRelatedWork W2559437906 @default.
• W2034294823 hasRelatedWork W2760854684 @default.
• W2034294823 hasRelatedWork W4234719082 @default.

• next