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- W2034295354 abstract "The structural requirements of corticosteroids were defined using the lateral root formation and the elongation growth of intact mung bean seedlings as bioassay. Only glucocorticoids possessing an 11-oxygen function stimulate the growth and the lateral root formation. 2α-Methylcortisol is an exception and inhibits growth. Mineralocorticoids inhibit the growth and the lateral root formation (11-deoxycortisol, DOC, aldosterone and the synthetic 2α-methyl, 9α-fluoro-cortisol). The 11β-OH-epimers of the glucocorticoids are more active than the corresponding 11-keto-forms. The small activity of 11α-epimers is not yet understood. Precursors of corticosteroids with an 11β-OH-group are very active, precursors lacking an 11-oxygen function are inactive or inhibitory. Of the reduced glucocorticoids at C-4 only the steroids with a 5β-hydrogen are active. The 5α-epimers are inactive or inhibitory. Reduction of the 3-oxo-group produces 3α-OH- and 3β-OH-forms. Only the 3α-OH-steroids were tested and these were as active as 3-oxo-steroids. Reduction of the 20-keto-group results in 20α- and 20β-OH-steroids that are equally active. Fully reduced glucocorticoids with 3α-OH, 5β-H and 20α- or 20β-OH are also active. The reduced 11-deoxycorticosteroids tested were inhibitory (DHS, THS, TH-DOC)." @default.
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- W2034295354 date "1983-07-01" @default.
- W2034295354 modified "2023-09-25" @default.
- W2034295354 title "Structural Requirements of Corticosteroids in Etiolated Mung Bean Seedlings" @default.
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- W2034295354 doi "https://doi.org/10.1016/s0044-328x(83)80040-3" @default.
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