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• W2034295402 abstract "Richter's transformation (RT) is the development of a high-grade lymphoma in patients with B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). We report an extremely rare case with paraimmunoblastic transformation. A 78-year-old Taiwanese male had Rai stage 1 and Binet stage B CLL/SLL involving skin, peripheral blood (PB), and bone marrow (BM) with paraimmunoblastic transformation in the lymph node. Molecular/genomic studies showed the same clonal origin of tumor tissues at various locations with trisomy 12 and a deletion of chromosome 13q14. Interestingly, there seemed to be no additional chromosomal aberrations in the transformed nodal tissue, suggesting that the micro-environment rather than an additional genetic lesion contributed to the transformation. The patient received chemotherapy and was alive with disease after 33.5 months." @default.
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• W2034295402 date "2010-04-01" @default.
• W2034295402 modified "2023-10-17" @default.
• W2034295402 title "Chronic lymphocytic leukemia with paraimmunoblastic transformation – with comparative genomic hybridization and review of the literature" @default.
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• W2034295402 doi "https://doi.org/10.1016/j.prp.2009.04.004" @default.
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