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• W2034296836 startingPage "79" @default.
• W2034296836 abstract "Abstract In order to study the role of platelets in Multiple Sclerosis (MS) we assessed, in a group of patients during a quiescent phase of the disease, the plasma levels of ß-thromboglobulin (ß-TG) and platelet factor four (PF4) both in absence of treatment and during administration of aspirin (ASA) at the dose of 50 mg/daily. In the MS patients studied, the basal plasma levels of ß-TG and PF4 were significantly higher than in control subjects. The increase in the ß-TG plasma levels occurred independently of the age, sex and severity of the disease, whereas the modification in the PF4 plasma levels was significantly correlated with the severity of the disease. Administration to the patients of ASA, at the dose that does not affect prostacyclin production, determined a decrease of ß-TG in 77% of the patients. Mean PF4 plasma levels remained unchanged. These results suggest that PF4 in the plasma of MS patients may originate not only from the platelets but also from the mast cells following platelet aggregating factor (PAF) stimulation and immunocomplex formation." @default.
• W2034296836 created "2016-06-24" @default.
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• W2034296836 date "1987-08-01" @default.
• W2034296836 modified "2023-09-23" @default.
• W2034296836 title "Relevance of platelet factor four (PF₄) plasma levels in multiple sclerosis" @default.
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• W2034296836 doi "https://doi.org/10.1111/j.1600-0404.1987.tb03550.x" @default.
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