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• W2034296851 abstract "The synthesis and biological activity of [Hyp4]morphiceptin and two glycosyl derivatives are reported. Glycopeptide amides were obtained using Fmoc solid-phase chemistry and mild conditions for cleavage from a tris(alkoxy)benzylamide (PAL) resin. Analogues were evaluated in the guinea pig ileum in vitro assay and in in vivo tail-flick and paw-pressure antinociceptive tests after intrathecal administration in rats. Substitution of Pro4 by Hypo4 and further derivatization of Hyp with glucose or galactose, resulted in an unexpected decrease in biological activity with respect to morphiceptin." @default.
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• W2034296851 date "1991-01-01" @default.
• W2034296851 modified "2023-10-03" @default.
• W2034296851 title "Synthesis and biological activity of O-glycosylated morphiceptin analogues" @default.
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• W2034296851 doi "https://doi.org/10.1039/p19910001755" @default.
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