Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034298085> ?p ?o ?g. }
- W2034298085 endingPage "e5190" @default.
- W2034298085 startingPage "e5190" @default.
- W2034298085 abstract "Cholera toxin (CT) is a potent vaccine adjuvant, which promotes mucosal immunity to protein antigen given by nasal route. It has been suggested that CT promotes T helper type 2 (Th2) response and suppresses Th1 response. We here report the induction of Th17-dominated responses in mice by intranasal delivery of CT. This dramatic Th17-driving effect of CT, which was dependent on the B subunit, was observed even in Th1 or Th2-favored conditions of respiratory virus infection. These dominating Th17 responses resulted in the significant neutrophil accumulation in the lungs of mice given CT. Both in vitro and in vivo treatment of CT induced strongly augmented IL-6 production, and Th17-driving ability of CT was completely abolished in IL-6 knockout mice, indicating a role of this cytokine in the Th17-dominated T-cell responses by CT. These data demonstrate a novel Th17-driving activity of CT, and help understand the mechanisms of CT adjuvanticity to demarcate T helper responses." @default.
- W2034298085 created "2016-06-24" @default.
- W2034298085 creator A5017165636 @default.
- W2034298085 creator A5020584360 @default.
- W2034298085 creator A5064273153 @default.
- W2034298085 creator A5081022899 @default.
- W2034298085 date "2009-04-10" @default.
- W2034298085 modified "2023-10-03" @default.
- W2034298085 title "Intranasal Delivery of Cholera Toxin Induces Th17-Dominated T-Cell Response to Bystander Antigens" @default.
- W2034298085 cites W1486323853 @default.
- W2034298085 cites W1526879038 @default.
- W2034298085 cites W1533878687 @default.
- W2034298085 cites W1537128240 @default.
- W2034298085 cites W1571426499 @default.
- W2034298085 cites W1602437032 @default.
- W2034298085 cites W1646384754 @default.
- W2034298085 cites W1865373094 @default.
- W2034298085 cites W1966371104 @default.
- W2034298085 cites W1967553195 @default.
- W2034298085 cites W1974844465 @default.
- W2034298085 cites W1975010250 @default.
- W2034298085 cites W1976862305 @default.
- W2034298085 cites W1998975199 @default.
- W2034298085 cites W2002204067 @default.
- W2034298085 cites W2002366487 @default.
- W2034298085 cites W2035313919 @default.
- W2034298085 cites W2040080235 @default.
- W2034298085 cites W2065915475 @default.
- W2034298085 cites W2075386186 @default.
- W2034298085 cites W2085230212 @default.
- W2034298085 cites W2100990607 @default.
- W2034298085 cites W2112133235 @default.
- W2034298085 cites W2112866067 @default.
- W2034298085 cites W2118011548 @default.
- W2034298085 cites W2125397987 @default.
- W2034298085 cites W2127254182 @default.
- W2034298085 cites W2128459026 @default.
- W2034298085 cites W2128721558 @default.
- W2034298085 cites W2135953287 @default.
- W2034298085 cites W2136145410 @default.
- W2034298085 cites W2139008734 @default.
- W2034298085 cites W2140160539 @default.
- W2034298085 cites W2142017607 @default.
- W2034298085 cites W2147103967 @default.
- W2034298085 cites W2149335164 @default.
- W2034298085 cites W2149849615 @default.
- W2034298085 cites W2149926345 @default.
- W2034298085 cites W2155779547 @default.
- W2034298085 cites W2163696227 @default.
- W2034298085 cites W2164521200 @default.
- W2034298085 cites W2172094131 @default.
- W2034298085 cites W2776663677 @default.
- W2034298085 doi "https://doi.org/10.1371/journal.pone.0005190" @default.
- W2034298085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663811" @default.
- W2034298085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360100" @default.
- W2034298085 hasPublicationYear "2009" @default.
- W2034298085 type Work @default.
- W2034298085 sameAs 2034298085 @default.
- W2034298085 citedByCount "82" @default.
- W2034298085 countsByYear W20342980852012 @default.
- W2034298085 countsByYear W20342980852013 @default.
- W2034298085 countsByYear W20342980852014 @default.
- W2034298085 countsByYear W20342980852015 @default.
- W2034298085 countsByYear W20342980852016 @default.
- W2034298085 countsByYear W20342980852017 @default.
- W2034298085 countsByYear W20342980852018 @default.
- W2034298085 countsByYear W20342980852019 @default.
- W2034298085 countsByYear W20342980852020 @default.
- W2034298085 countsByYear W20342980852021 @default.
- W2034298085 countsByYear W20342980852022 @default.
- W2034298085 countsByYear W20342980852023 @default.
- W2034298085 crossrefType "journal-article" @default.
- W2034298085 hasAuthorship W2034298085A5017165636 @default.
- W2034298085 hasAuthorship W2034298085A5020584360 @default.
- W2034298085 hasAuthorship W2034298085A5064273153 @default.
- W2034298085 hasAuthorship W2034298085A5081022899 @default.
- W2034298085 hasBestOaLocation W20342980851 @default.
- W2034298085 hasConcept C126322002 @default.
- W2034298085 hasConcept C147483822 @default.
- W2034298085 hasConcept C150903083 @default.
- W2034298085 hasConcept C170493617 @default.
- W2034298085 hasConcept C182704531 @default.
- W2034298085 hasConcept C19106626 @default.
- W2034298085 hasConcept C203014093 @default.
- W2034298085 hasConcept C207001950 @default.
- W2034298085 hasConcept C2776090121 @default.
- W2034298085 hasConcept C2777006276 @default.
- W2034298085 hasConcept C2777863537 @default.
- W2034298085 hasConcept C2778690821 @default.
- W2034298085 hasConcept C2781136212 @default.
- W2034298085 hasConcept C71924100 @default.
- W2034298085 hasConcept C85663871 @default.
- W2034298085 hasConcept C86803240 @default.
- W2034298085 hasConcept C8891405 @default.
- W2034298085 hasConcept C89423630 @default.
- W2034298085 hasConceptScore W2034298085C126322002 @default.
- W2034298085 hasConceptScore W2034298085C147483822 @default.
- W2034298085 hasConceptScore W2034298085C150903083 @default.