FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034300049> ?p ?o ?g. }

• W2034300049 endingPage "1457" @default.
• W2034300049 startingPage "1456" @default.
• W2034300049 abstract "Metabolic incorporation of 3H-thymidine into cellular DNA is a widely used protocol to monitor rates of DNA synthesis and cell proliferation. However, this radiochemical has also been reported to induce cell-cycle arrest and apoptosis in addition to DNA damage. Using stable isotope-labeled thymidine, we demonstrate that 3H-thymidine induces dose-dependent inhibition of the rate of DNA synthesis. This inhibition occurred within the first round of replication after addition of the radiolabeled tracer and demonstrates the cytotoxic effects of conventional doses of 3H-thymidine (typically greater than or equal to 1 microCi/ml). These results thus show that stable isotope methods are superior to radioisotopes for determining rates of DNA synthesis and cell replication. Because 3H-thymidine perturbs the very process it was employed to study, experiments using 3H-thymidine to monitor DNA synthesis and cell proliferation should be interpreted with caution." @default.
• W2034300049 created "2016-06-24" @default.
• W2034300049 creator A5001474444 @default.
• W2034300049 creator A5051133630 @default.
• W2034300049 creator A5085786328 @default.
• W2034300049 creator A5088382882 @default.
• W2034300049 date "2002-07-01" @default.
• W2034300049 modified "2023-09-27" @default.
• W2034300049 title "³ H‐thymidine is a defective tool with which to measure rates of DNA synthesis" @default.
• W2034300049 cites W1853269105 @default.
• W2034300049 cites W1975339033 @default.
• W2034300049 cites W1982821013 @default.
• W2034300049 cites W1985620441 @default.
• W2034300049 cites W1989535037 @default.
• W2034300049 cites W2003565910 @default.
• W2034300049 cites W2005354143 @default.
• W2034300049 cites W2014784452 @default.
• W2034300049 cites W2025052382 @default.
• W2034300049 cites W2037932319 @default.
• W2034300049 cites W2040879809 @default.
• W2034300049 cites W2068136858 @default.
• W2034300049 cites W2082204121 @default.
• W2034300049 cites W2098058543 @default.
• W2034300049 cites W2131980552 @default.
• W2034300049 cites W2155507496 @default.
• W2034300049 cites W2160483159 @default.
• W2034300049 cites W2164217471 @default.
• W2034300049 cites W2327150305 @default.
• W2034300049 cites W2483430400 @default.
• W2034300049 doi "https://doi.org/10.1096/fj.02-0142fje" @default.
• W2034300049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12205046" @default.
• W2034300049 hasPublicationYear "2002" @default.
• W2034300049 type Work @default.
• W2034300049 sameAs 2034300049 @default.
• W2034300049 citedByCount "46" @default.
• W2034300049 countsByYear W20343000492012 @default.
• W2034300049 countsByYear W20343000492013 @default.
• W2034300049 countsByYear W20343000492014 @default.
• W2034300049 countsByYear W20343000492015 @default.
• W2034300049 countsByYear W20343000492016 @default.
• W2034300049 countsByYear W20343000492017 @default.
• W2034300049 countsByYear W20343000492018 @default.
• W2034300049 countsByYear W20343000492019 @default.
• W2034300049 countsByYear W20343000492020 @default.
• W2034300049 countsByYear W20343000492021 @default.
• W2034300049 countsByYear W20343000492022 @default.
• W2034300049 countsByYear W20343000492023 @default.
• W2034300049 crossrefType "journal-article" @default.
• W2034300049 hasAuthorship W2034300049A5001474444 @default.
• W2034300049 hasAuthorship W2034300049A5051133630 @default.
• W2034300049 hasAuthorship W2034300049A5085786328 @default.
• W2034300049 hasAuthorship W2034300049A5088382882 @default.
• W2034300049 hasBestOaLocation W20343000491 @default.
• W2034300049 hasConcept C1491633281 @default.
• W2034300049 hasConcept C153911025 @default.
• W2034300049 hasConcept C177322064 @default.
• W2034300049 hasConcept C185592680 @default.
• W2034300049 hasConcept C2777108182 @default.
• W2034300049 hasConcept C29537977 @default.
• W2034300049 hasConcept C552990157 @default.
• W2034300049 hasConcept C55493867 @default.
• W2034300049 hasConcept C62112901 @default.
• W2034300049 hasConcept C64241487 @default.
• W2034300049 hasConcept C73573662 @default.
• W2034300049 hasConcept C86803240 @default.
• W2034300049 hasConceptScore W2034300049C1491633281 @default.
• W2034300049 hasConceptScore W2034300049C153911025 @default.
• W2034300049 hasConceptScore W2034300049C177322064 @default.
• W2034300049 hasConceptScore W2034300049C185592680 @default.
• W2034300049 hasConceptScore W2034300049C2777108182 @default.
• W2034300049 hasConceptScore W2034300049C29537977 @default.
• W2034300049 hasConceptScore W2034300049C552990157 @default.
• W2034300049 hasConceptScore W2034300049C55493867 @default.
• W2034300049 hasConceptScore W2034300049C62112901 @default.
• W2034300049 hasConceptScore W2034300049C64241487 @default.
• W2034300049 hasConceptScore W2034300049C73573662 @default.
• W2034300049 hasConceptScore W2034300049C86803240 @default.
• W2034300049 hasFunder F4320306076 @default.
• W2034300049 hasFunder F4320332505 @default.
• W2034300049 hasIssue "11" @default.
• W2034300049 hasLocation W20343000491 @default.
• W2034300049 hasLocation W20343000492 @default.
• W2034300049 hasOpenAccess W2034300049 @default.
• W2034300049 hasPrimaryLocation W20343000491 @default.
• W2034300049 hasRelatedWork W1605122871 @default.
• W2034300049 hasRelatedWork W1966463541 @default.
• W2034300049 hasRelatedWork W1990298640 @default.
• W2034300049 hasRelatedWork W2023487384 @default.
• W2034300049 hasRelatedWork W2026118442 @default.
• W2034300049 hasRelatedWork W2047226902 @default.
• W2034300049 hasRelatedWork W2054955960 @default.
• W2034300049 hasRelatedWork W2065565203 @default.
• W2034300049 hasRelatedWork W2068356852 @default.
• W2034300049 hasRelatedWork W2188634349 @default.
• W2034300049 hasVolume "16" @default.
• W2034300049 isParatext "false" @default.
• W2034300049 isRetracted "false" @default.
• W2034300049 magId "2034300049" @default.

• next