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- W2034300062 abstract "Premature ovaryen yetmezlik (POY), 40 yas oncesi, amenore, dusuk ostrojen ve yuksek gonadotropin hormon duzeyleri ile karakterize olan, kadin infertilitesinin en onemli nedenlerinden biridir. Patogenezinde, genetik, otoimmun ve cevresel faktorler rol oynayabilir. Bu calismada Ondokuz Mayis Universitesi, Tip Fakultesi, Kadin Hastaliklari ve Dogum polikliniginden laboratuvarimiza gonderilen premature ovaryen yetmezligi olan 22 yasinda bir kadin olguyu inceledik. Konvansiyonel sitogenetik analizde X kromozomun uzun kolunda delesyon 46,X,del(X)(q21) gozlendi. Bu bulgu premature ovaryen yetmezliginde X kromozom delesyonunun onemini bir kez daha vurgulamistir.Premature ovarian failure and 46,X,del(X)(q21)Premature ovarian failure (POF) is a common cause of infertility in women, and is characterised by amenorrhoea, hypo-oestrogenism and elevated gonadotrophin levels in women under the age of 40. Genetic, autoimmune and the environmental factors play a role in the pathogenesis. In this study, we investigated a 22 year-old woman having premature ovarian failure, referred to our laboratuary from Ondokuz Mayis University Gynecology and Obstetrics polyclinic. In conventional cytogenetic analysis, a deletion was observed in the long arm of the X chromosome 46,X,del(X)(q21). This finding was emphasised once again the significance of X chromosome deletions in the premature ovarian failure.J. Exp. Clin. Med., 2012; 29:167-168" @default.
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- W2034300062 date "2012-07-16" @default.
- W2034300062 modified "2023-10-18" @default.
- W2034300062 title "Prematüre ovaryen yetmezlik ve 46,X,del(X)(q21)" @default.
- W2034300062 doi "https://doi.org/10.5835/jecm.omu.29.02.018" @default.
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