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• W2034301098 abstract "The transient rise of intracellular Ca 2+ in detrusor smooth muscle cells is due to the release of Ca 2+ from intracellular stores. However, it is not known how store refilling is maintained at a constant level to ensure constancy of the contractile response. The aim of these experiments was to characterise the role of L‐type Ca 2+ channels in refilling. Experiments used isolated guinea‐pig detrusor myocytes and store Ca 2+ content was estimated by measuring the magnitude of change to the intracellular [Ca 2+ ] ([Ca 2+ ] i ) after application of caffeine or carbachol using epifluorescence microscopy. Membrane potential was controlled when necessary by voltage clamp. After Ca 2+ stores were emptied they refilled with an exponential time course, with a time constant of 88 s. The value of the time constant was similar to that of the undershoot of [Ca 2+ ] i following store Ca 2+ release. The degree of store filling was enhanced by maintained depolarisation, or by transient depolarising pulses, and attenuated by L‐type Ca 2+ channel antagonists. Inhibition of the sarcoplasmic reticular Ca 2+ ‐ATPase prevented refilling. Reduction of the resting [Ca 2+ ] i was accompanied by membrane depolarisation; under voltage clamp reduction of [Ca 2+ ] i decreased the number and magnitude of spontaneous transient outward currents. Ca 2+ release from intracellular stores, elicited by caffeine or carbachol, is independent of membrane potential under physiological conditions. However, store refilling occurs via Ca 2+ influx through L‐type Ca 2+ channels. Ca 2+ influx is regulated by a feedback mechanism whereby a fall of [Ca 2+ ] i reduces the activity of Ca 2+ ‐activated K + channels, causing cell depolarisation and an enhancement of L‐type Ca 2+ channel conductance." @default.
• W2034301098 created "2016-06-24" @default.
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• W2034301098 date "2002-01-01" @default.
• W2034301098 modified "2023-10-18" @default.
• W2034301098 title "The role of the L‐type Ca²⁺ channel in refilling functional intracellular Ca²⁺ stores in guinea‐pig detrusor smooth muscle" @default.
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• W2034301098 doi "https://doi.org/10.1113/jphysiol.2001.013191" @default.
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