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• W2034301663 startingPage "79" @default.
• W2034301663 abstract "Intermediate filaments are a major component of the cytoskeleton of higher eukaryotes. These filaments are composed of a number of different, although structurally related, proteins. Different intermediate filament protein genes are expressed in different tissues. Spontaneous and experimentally produced mutations in the intermediate filament genes indicate that these filaments function to enhance the mechanical stability of epidermal and muscle cells. As a result, the use of transgenic mice with knockout or dominant negative mutations in IF genes has become an important approach for investigating the significance of IFs in other cell types. However, a knockout mutation of vimentin (-/-), the intermediate filament protein characteristically expressed in cells of mesenchymal origin, results in very subtle phenotypes that are not obviously related to cell fragility. Although experiments with cultured cells have described a variety of discrete changes in cell properties that are associated with vimentin expression or organization, there is no evidence yet that any of these properties are affected in the vimentin-/- mouse." @default.
• W2034301663 created "2016-06-24" @default.
• W2034301663 creator A5024127409 @default.
• W2034301663 date "1998-12-06" @default.
• W2034301663 modified "2023-10-16" @default.
• W2034301663 title "Vimentin: the conundrum of the intermediate filament gene family" @default.
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• W2034301663 doi "https://doi.org/10.1002/(sici)1521-1878(199801)20:1<79::aid-bies11>3.0.co;2-5" @default.
• W2034301663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9504050" @default.
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