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- W2034301890 abstract "We used in situ hybridization of 35S-labeled antisense RNAs to study the cellular distribution of three neuronal mRNAs. We compared the expression of these RNAs in cerebellar Purkinje neurons in wild-type (C57Bl-6J) mice and in two mutants (Weaver and reeler) known to have abnormal cerebellar morphologies. In normal mice, GAD mRNA is present in four sets of neurons in the cerebellar cortex while calbindin mRNA is present only in Purkinje neurons. Proenkephalin mRNA is present in Golgi II neurons as well as in a set of neurons in the deep part of the molecular layer. Despite the dramatic differences in structural organization and inputs of Purkinje neurons in the cerebella of adult Weaver and reeler mice, the expression of these RNAs appears unchanged. These results support the hypothesis that Purkinje cell cytodifferentiation proceeds autonomously after its inception in early embryonic life." @default.
- W2034301890 created "2016-06-24" @default.
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- W2034301890 date "1988-11-01" @default.
- W2034301890 modified "2023-09-24" @default.
- W2034301890 title "The abnormal cerebellar organization of weaver and reeler mice does not affect the cellular distribution of three neuronal mRNAs" @default.
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- W2034301890 doi "https://doi.org/10.1016/0896-6273(88)90128-6" @default.
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