FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034302165> ?p ?o ?g. }

• W2034302165 endingPage "489" @default.
• W2034302165 startingPage "477" @default.
• W2034302165 abstract "Abstract Circadian rhythms of many body functions in mammals are controlled by a master pacemaker, residing in the hypothalamic suprachiasmatic nucleus (SCN), which synchronises peripheral oscillators. The SCN and peripheral oscillators share several components of the molecular clockwork and comprise transcriptional activators (BMAL1 and CLOCK/NPAS2) and inhibitors (mPER1/2 and mCRY1/2). Here we compared the ontogenetic maturation of the clockwork in the SCN and pars tuberalis (PT). The PT is a peripheral oscillator that strongly depends on rhythmic melatonin signals. Immunoreactions for clock gene proteins were determined in the SCN and PT at four different timepoints during four differential stages of mouse ontogeny: foetal (embryonic day 18), newborn (2‐day‐old), infantile (10‐day‐old), and adult. In the foetal SCN, levels of immunoreactions of all clock proteins were significantly lower than adult levels except for BMAL1. In the newborn SCN the clock protein immunoreactions had not yet reached adult levels, but the infantile SCN showed similar levels of immunoreactions as the adult. In contrast, immunoreactions for all clock gene proteins in the foetal PT were as intense as in newborn, infantile and adult, and showed the same phase. As the foetal pineal gland is not yet capable of rhythmic melatonin production, the rhythms in clock gene proteins in the foetal PT are presumably dependent on the maternal melatonin signal. Thus, our data provide the first evidence that maternal melatonin is important for establishing and maintaining circadian rhythms in a foetal peripheral oscillator." @default.
• W2034302165 created "2016-06-24" @default.
• W2034302165 creator A5006590266 @default.
• W2034302165 creator A5025722276 @default.
• W2034302165 creator A5033872363 @default.
• W2034302165 creator A5078813022 @default.
• W2034302165 creator A5080245206 @default.
• W2034302165 date "2009-02-01" @default.
• W2034302165 modified "2023-10-12" @default.
• W2034302165 title "Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny" @default.
• W2034302165 cites W1583476908 @default.
• W2034302165 cites W1585713057 @default.
• W2034302165 cites W1851766745 @default.
• W2034302165 cites W1906903038 @default.
• W2034302165 cites W1919235255 @default.
• W2034302165 cites W1967635499 @default.
• W2034302165 cites W1967984848 @default.
• W2034302165 cites W1972142783 @default.
• W2034302165 cites W1976075252 @default.
• W2034302165 cites W1982104209 @default.
• W2034302165 cites W1989011389 @default.
• W2034302165 cites W1991021245 @default.
• W2034302165 cites W1996679288 @default.
• W2034302165 cites W2003302378 @default.
• W2034302165 cites W2007344050 @default.
• W2034302165 cites W2012509672 @default.
• W2034302165 cites W2013657378 @default.
• W2034302165 cites W2013855904 @default.
• W2034302165 cites W2014313900 @default.
• W2034302165 cites W2028113817 @default.
• W2034302165 cites W2040192661 @default.
• W2034302165 cites W2041136510 @default.
• W2034302165 cites W2049285778 @default.
• W2034302165 cites W2053414344 @default.
• W2034302165 cites W2061311147 @default.
• W2034302165 cites W2062731932 @default.
• W2034302165 cites W2066183013 @default.
• W2034302165 cites W2068429888 @default.
• W2034302165 cites W2069425055 @default.
• W2034302165 cites W2076640453 @default.
• W2034302165 cites W2076794882 @default.
• W2034302165 cites W2084337872 @default.
• W2034302165 cites W2090816060 @default.
• W2034302165 cites W2091374027 @default.
• W2034302165 cites W2093344683 @default.
• W2034302165 cites W2093526792 @default.
• W2034302165 cites W2101116112 @default.
• W2034302165 cites W2108132856 @default.
• W2034302165 cites W2113511986 @default.
• W2034302165 cites W2120625660 @default.
• W2034302165 cites W2127447141 @default.
• W2034302165 cites W2128564208 @default.
• W2034302165 cites W2132443457 @default.
• W2034302165 cites W2139766030 @default.
• W2034302165 cites W2141401639 @default.
• W2034302165 cites W2145237902 @default.
• W2034302165 cites W2153447419 @default.
• W2034302165 cites W2169220425 @default.
• W2034302165 cites W2169935996 @default.
• W2034302165 doi "https://doi.org/10.1111/j.1460-9568.2008.06605.x" @default.
• W2034302165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2651153" @default.
• W2034302165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19222558" @default.
• W2034302165 hasPublicationYear "2009" @default.
• W2034302165 type Work @default.
• W2034302165 sameAs 2034302165 @default.
• W2034302165 citedByCount "59" @default.
• W2034302165 countsByYear W20343021652012 @default.
• W2034302165 countsByYear W20343021652013 @default.
• W2034302165 countsByYear W20343021652014 @default.
• W2034302165 countsByYear W20343021652015 @default.
• W2034302165 countsByYear W20343021652016 @default.
• W2034302165 countsByYear W20343021652017 @default.
• W2034302165 countsByYear W20343021652018 @default.
• W2034302165 countsByYear W20343021652019 @default.
• W2034302165 countsByYear W20343021652020 @default.
• W2034302165 countsByYear W20343021652021 @default.
• W2034302165 countsByYear W20343021652022 @default.
• W2034302165 countsByYear W20343021652023 @default.
• W2034302165 crossrefType "journal-article" @default.
• W2034302165 hasAuthorship W2034302165A5006590266 @default.
• W2034302165 hasAuthorship W2034302165A5025722276 @default.
• W2034302165 hasAuthorship W2034302165A5033872363 @default.
• W2034302165 hasAuthorship W2034302165A5078813022 @default.
• W2034302165 hasAuthorship W2034302165A5080245206 @default.
• W2034302165 hasBestOaLocation W20343021652 @default.
• W2034302165 hasConcept C121446783 @default.
• W2034302165 hasConcept C126322002 @default.
• W2034302165 hasConcept C134018914 @default.
• W2034302165 hasConcept C169760540 @default.
• W2034302165 hasConcept C184738001 @default.
• W2034302165 hasConcept C201176492 @default.
• W2034302165 hasConcept C2777003273 @default.
• W2034302165 hasConcept C2777658017 @default.
• W2034302165 hasConcept C2778182776 @default.
• W2034302165 hasConcept C2779317972 @default.
• W2034302165 hasConcept C2779424673 @default.
• W2034302165 hasConcept C38606739 @default.
• W2034302165 hasConcept C71315377 @default.

• next