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• W2034302514 endingPage "1028" @default.
• W2034302514 startingPage "1021" @default.
• W2034302514 abstract "NANOG and OCT4 are required for the maintenance of pluripotency in embryonic stem cells (ESCs). These proteins are also expressed in the inner cell mass (ICM) of the mouse pre-implantation embryo. Immunohistochemistry was used to show the presence of NANOG and OCT4 protein, and in situ hybridization was used to localize NANOG mRNA in human embryos from two-cell to blastocyst stage, and in human ESCs (hESCs). Nanog and Oct4 were co-localized in human embryos from morula and blastocyst stages. NANOG mRNA was detected in a group of cells in the morula, in cells of the ICM of blastocysts, and evenly in hESCs. All non-differentiated hESCs expressed NANOG and OCT4 protein. Pluripotent cells expressing NANOG and Oct4 were eccentrically localized, probably in polarized cells in a human compacted morula, which appears to be different from expression in murine embryos. In this study, we demonstrate that whole mount in situ hybridization is amenable to localization of mRNAs in human development, as in other species." @default.
• W2034302514 created "2016-06-24" @default.
• W2034302514 creator A5024730847 @default.
• W2034302514 creator A5039791065 @default.
• W2034302514 creator A5066177065 @default.
• W2034302514 creator A5066805987 @default.
• W2034302514 date "2012-06-29" @default.
• W2034302514 modified "2023-10-15" @default.
• W2034302514 title "Co-localization of NANOG and OCT4 in human pre-implantation embryos and in human embryonic stem cells" @default.
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• W2034302514 doi "https://doi.org/10.1007/s10815-012-9824-9" @default.
• W2034302514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3492569" @default.
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