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- W2034302602 abstract "Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; show that much fluid therapy is clinically ineffective in patients with severe sepsis; explore the detrimental aspects of excessive volume infusion; examine how clinicians assess the intravascular volume state; appraise the potential for dynamic indexes to predict fluid responsiveness; and recommend a clinical approach. Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; show that much fluid therapy is clinically ineffective in patients with severe sepsis; explore the detrimental aspects of excessive volume infusion; examine how clinicians assess the intravascular volume state; appraise the potential for dynamic indexes to predict fluid responsiveness; and recommend a clinical approach." @default.
- W2034302602 created "2016-06-24" @default.
- W2034302602 creator A5014343783 @default.
- W2034302602 creator A5077731816 @default.
- W2034302602 date "2008-01-01" @default.
- W2034302602 modified "2023-10-01" @default.
- W2034302602 title "Fluid Therapy in Resuscitated Sepsis" @default.
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- W2034302602 doi "https://doi.org/10.1378/chest.07-1496" @default.
- W2034302602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18187750" @default.
- W2034302602 hasPublicationYear "2008" @default.
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