Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034303637> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2034303637 endingPage "27" @default.
- W2034303637 startingPage "19" @default.
- W2034303637 abstract "Acute cyanide (CN) toxicity was investigated in the Sprague-Dawley rat. Conscious, loosely restrained rats received sodium CN solution at varying dose rates through a jugular cannula (low CN, 0.077-0.155 mg/kg/min; high CN, 0.157-0.204 mg/kg/min). Blood glucose concentration was significantly increased 45 min after initial CN treatment in both the low and the high CN groups compared to the saline controls. Blood lactate concentration was significantly increased only in the high CN group after 45 min. Lactate increased directly with CN dose rate in surviving high CN rats. In rats that succumbed during CN infusion, lactate concentration reached nearly 150 mg/dl. Body temperature decreased modestly at low CN dose rates, but increased markedly at high CN dose rates. Heart rate was relatively constant in the low CN group, but decreased rapidly in the high CN group with increasing CN dose rate. In rats surviving CN treatment, no significant alterations in either cerebral cortical water content or neurologic status were detected. This contrasts with another potent poison, carbon monoxide, which produces marked neurologic deficit and cerebral edema in this animal model. The mean lethal CN dose was 4.6 mg/kg (range 4.25-4.90 mg/kg). Expressed on the basis of CN infusion rate, the lethal zone was from 0.16 to 0.21 mg/kg/min, a surprisingly narrow range. Assuming that extrapolations are possible to other species, the data provide strong evidence that greatly elevated blood lactate may be a useful marker for CN poisoning very near or within the lethal zone." @default.
- W2034303637 created "2016-06-24" @default.
- W2034303637 creator A5044732928 @default.
- W2034303637 creator A5047821208 @default.
- W2034303637 date "1995-01-01" @default.
- W2034303637 modified "2023-10-13" @default.
- W2034303637 title "Metabolic, cardiovascular, and neurologic aspects of acute cyanide poisoning in the rat" @default.
- W2034303637 cites W1963788448 @default.
- W2034303637 cites W1965978234 @default.
- W2034303637 cites W1991446180 @default.
- W2034303637 cites W1993332131 @default.
- W2034303637 cites W2002678455 @default.
- W2034303637 cites W2004525310 @default.
- W2034303637 cites W2013354636 @default.
- W2034303637 cites W2016410439 @default.
- W2034303637 cites W2025855773 @default.
- W2034303637 cites W2025878601 @default.
- W2034303637 cites W2048753377 @default.
- W2034303637 cites W2074969668 @default.
- W2034303637 cites W2091931436 @default.
- W2034303637 cites W2141034752 @default.
- W2034303637 cites W2149695214 @default.
- W2034303637 cites W2319807427 @default.
- W2034303637 cites W2326719378 @default.
- W2034303637 cites W4230262688 @default.
- W2034303637 doi "https://doi.org/10.1016/0378-4274(94)03152-w" @default.
- W2034303637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7863526" @default.
- W2034303637 hasPublicationYear "1995" @default.
- W2034303637 type Work @default.
- W2034303637 sameAs 2034303637 @default.
- W2034303637 citedByCount "12" @default.
- W2034303637 countsByYear W20343036372014 @default.
- W2034303637 countsByYear W20343036372016 @default.
- W2034303637 countsByYear W20343036372018 @default.
- W2034303637 countsByYear W20343036372021 @default.
- W2034303637 countsByYear W20343036372023 @default.
- W2034303637 crossrefType "journal-article" @default.
- W2034303637 hasAuthorship W2034303637A5044732928 @default.
- W2034303637 hasAuthorship W2034303637A5047821208 @default.
- W2034303637 hasConcept C116263406 @default.
- W2034303637 hasConcept C126322002 @default.
- W2034303637 hasConcept C134018914 @default.
- W2034303637 hasConcept C140793950 @default.
- W2034303637 hasConcept C141071460 @default.
- W2034303637 hasConcept C179104552 @default.
- W2034303637 hasConcept C185592680 @default.
- W2034303637 hasConcept C2777397205 @default.
- W2034303637 hasConcept C2778074680 @default.
- W2034303637 hasConcept C2778455166 @default.
- W2034303637 hasConcept C29730261 @default.
- W2034303637 hasConcept C42219234 @default.
- W2034303637 hasConcept C71924100 @default.
- W2034303637 hasConcept C86803240 @default.
- W2034303637 hasConceptScore W2034303637C116263406 @default.
- W2034303637 hasConceptScore W2034303637C126322002 @default.
- W2034303637 hasConceptScore W2034303637C134018914 @default.
- W2034303637 hasConceptScore W2034303637C140793950 @default.
- W2034303637 hasConceptScore W2034303637C141071460 @default.
- W2034303637 hasConceptScore W2034303637C179104552 @default.
- W2034303637 hasConceptScore W2034303637C185592680 @default.
- W2034303637 hasConceptScore W2034303637C2777397205 @default.
- W2034303637 hasConceptScore W2034303637C2778074680 @default.
- W2034303637 hasConceptScore W2034303637C2778455166 @default.
- W2034303637 hasConceptScore W2034303637C29730261 @default.
- W2034303637 hasConceptScore W2034303637C42219234 @default.
- W2034303637 hasConceptScore W2034303637C71924100 @default.
- W2034303637 hasConceptScore W2034303637C86803240 @default.
- W2034303637 hasIssue "1-3" @default.
- W2034303637 hasLocation W20343036371 @default.
- W2034303637 hasLocation W20343036372 @default.
- W2034303637 hasOpenAccess W2034303637 @default.
- W2034303637 hasPrimaryLocation W20343036371 @default.
- W2034303637 hasRelatedWork W153556183 @default.
- W2034303637 hasRelatedWork W2282512389 @default.
- W2034303637 hasRelatedWork W2343621127 @default.
- W2034303637 hasRelatedWork W2355288997 @default.
- W2034303637 hasRelatedWork W2414402440 @default.
- W2034303637 hasRelatedWork W2460212561 @default.
- W2034303637 hasRelatedWork W254667111 @default.
- W2034303637 hasRelatedWork W2557075114 @default.
- W2034303637 hasRelatedWork W4301937111 @default.
- W2034303637 hasRelatedWork W791954815 @default.
- W2034303637 hasVolume "75" @default.
- W2034303637 isParatext "false" @default.
- W2034303637 isRetracted "false" @default.
- W2034303637 magId "2034303637" @default.
- W2034303637 workType "article" @default.