Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034304864> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034304864 endingPage "576" @default.
- W2034304864 startingPage "570" @default.
- W2034304864 abstract "Restoration of flow-dependent coronary artery dilation by angiotensin-converting enzyme inhibition (ACEI) has been demonstrated in patients with hypertension. The aim of the present study was to evaluate whether dilation of conductance coronary arteries may alter maximal coronary blood flow (CBFmax) and minimal coronary resistance (CRmin) in hypertensive patients with reversible impairment of flow-dependent coronary artery dilation. Thirteen hypertensive patients with angiographically normal coronary arteries and no other risk factors were studied. Cross-sectional areas (CSAs) of proximal and distal left anterior descending (LAD) coronary arteries were determined by quantitative angiography. Coronary flow velocity was recorded in the distal LAD with an intracoronary Doppler catheter. Estimates of coronary blood flow and resistance were calculated at rest and during maximal increase in blood flow induced by papaverine injected in the midportion of the LAD, both before and after ACEI. Flow-dependent dilation of the proximal LAD, abolished before ACEI, was restored after (26.7 +/- 11.2%; p < 0.001). The increase in CSA of the distal LAD exposed to papaverine was significantly higher after ACEI than before (from 33.4 +/- 20.5% to 51.5 +/- 23.4%; p < 0.001). After restoration of proximal LAD flow-dependent dilation, CBFmax was increased by +21.0 +/- 10.3% (p < 0.001), and CRmin was reduced by 19.3 +/- 9.5% (p < 0.001). Thus, dilation of epicardial coronary arteries participates substantially in the coronary resistance in hypertensive patients. Restoration of flow-dependent coronary artery dilation by ACEI may improve the ability of coronary circulation to deliver its maximal myocardial blood flow in hypertensive patients." @default.
- W2034304864 created "2016-06-24" @default.
- W2034304864 creator A5009920842 @default.
- W2034304864 creator A5045627296 @default.
- W2034304864 creator A5046672246 @default.
- W2034304864 creator A5057820956 @default.
- W2034304864 date "2000-11-01" @default.
- W2034304864 modified "2023-09-25" @default.
- W2034304864 title "Restoration of Flow-Dependent Coronary Dilation by ACE Inhibition Improves Papaverine-Induced Maximal Coronary Blood Flow in Hypertensive Patients: Demonstration That Large Epicardial Coronary Arteries are More Than Conductance Vessels" @default.
- W2034304864 cites W1968264611 @default.
- W2034304864 cites W1971261277 @default.
- W2034304864 cites W1975475560 @default.
- W2034304864 cites W1983322810 @default.
- W2034304864 cites W2003233163 @default.
- W2034304864 cites W2004472687 @default.
- W2034304864 cites W2014639523 @default.
- W2034304864 cites W2018106877 @default.
- W2034304864 cites W2024380450 @default.
- W2034304864 cites W2024524546 @default.
- W2034304864 cites W2030430514 @default.
- W2034304864 cites W2030537932 @default.
- W2034304864 cites W2035199836 @default.
- W2034304864 cites W2035610186 @default.
- W2034304864 cites W2077130091 @default.
- W2034304864 cites W2082117302 @default.
- W2034304864 cites W2087375327 @default.
- W2034304864 cites W2134722705 @default.
- W2034304864 cites W2158602005 @default.
- W2034304864 cites W2344300526 @default.
- W2034304864 cites W4299696637 @default.
- W2034304864 doi "https://doi.org/10.1097/00005344-200011000-00005" @default.
- W2034304864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11065216" @default.
- W2034304864 hasPublicationYear "2000" @default.
- W2034304864 type Work @default.
- W2034304864 sameAs 2034304864 @default.
- W2034304864 citedByCount "3" @default.
- W2034304864 crossrefType "journal-article" @default.
- W2034304864 hasAuthorship W2034304864A5009920842 @default.
- W2034304864 hasAuthorship W2034304864A5045627296 @default.
- W2034304864 hasAuthorship W2034304864A5046672246 @default.
- W2034304864 hasAuthorship W2034304864A5057820956 @default.
- W2034304864 hasBestOaLocation W20343048641 @default.
- W2034304864 hasConcept C126322002 @default.
- W2034304864 hasConcept C158846371 @default.
- W2034304864 hasConcept C164705383 @default.
- W2034304864 hasConcept C2776157398 @default.
- W2034304864 hasConcept C2776820930 @default.
- W2034304864 hasConcept C2776952824 @default.
- W2034304864 hasConcept C2778707443 @default.
- W2034304864 hasConcept C2778742706 @default.
- W2034304864 hasConcept C71924100 @default.
- W2034304864 hasConceptScore W2034304864C126322002 @default.
- W2034304864 hasConceptScore W2034304864C158846371 @default.
- W2034304864 hasConceptScore W2034304864C164705383 @default.
- W2034304864 hasConceptScore W2034304864C2776157398 @default.
- W2034304864 hasConceptScore W2034304864C2776820930 @default.
- W2034304864 hasConceptScore W2034304864C2776952824 @default.
- W2034304864 hasConceptScore W2034304864C2778707443 @default.
- W2034304864 hasConceptScore W2034304864C2778742706 @default.
- W2034304864 hasConceptScore W2034304864C71924100 @default.
- W2034304864 hasIssue "5" @default.
- W2034304864 hasLocation W20343048641 @default.
- W2034304864 hasLocation W20343048642 @default.
- W2034304864 hasLocation W20343048643 @default.
- W2034304864 hasOpenAccess W2034304864 @default.
- W2034304864 hasPrimaryLocation W20343048641 @default.
- W2034304864 hasRelatedWork W116287898 @default.
- W2034304864 hasRelatedWork W1990153877 @default.
- W2034304864 hasRelatedWork W2022750242 @default.
- W2034304864 hasRelatedWork W2061674629 @default.
- W2034304864 hasRelatedWork W2071806485 @default.
- W2034304864 hasRelatedWork W2087904796 @default.
- W2034304864 hasRelatedWork W2397775925 @default.
- W2034304864 hasRelatedWork W2427904558 @default.
- W2034304864 hasRelatedWork W2905793829 @default.
- W2034304864 hasRelatedWork W587608438 @default.
- W2034304864 hasVolume "36" @default.
- W2034304864 isParatext "false" @default.
- W2034304864 isRetracted "false" @default.
- W2034304864 magId "2034304864" @default.
- W2034304864 workType "article" @default.