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• W2034305079 startingPage "e30733" @default.
• W2034305079 abstract "Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. Statistical estimates and biochemical assays provided strong evidence that a substantial fraction of the spliced transcripts from hundreds of genes are circular RNAs. Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells." @default.
• W2034305079 created "2016-06-24" @default.
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• W2034305079 date "2012-02-01" @default.
• W2034305079 modified "2023-10-10" @default.
• W2034305079 title "Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types" @default.
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• W2034305079 doi "https://doi.org/10.1371/journal.pone.0030733" @default.
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