Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034305770> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034305770 endingPage "782" @default.
- W2034305770 startingPage "777" @default.
- W2034305770 abstract "Forty-seven patients with muscle-invasive bladder cancer (T2-T4, Nx, M0) were treated by transurethral resection, followed by 3-4 cycles of combination chemotherapy (methotrexate 30 mg/m2 on days 1, 14; cis-platinum 100 mg/m2 on day 2; vinblastine 3 mg/m2 on days 1, 14; repeated every 21 days), and external beam irradiation (64-66 Gy to the bladder and 40 Gy to the pelvic lymphatics). Complete remission after trans urethral resection and chemotherapy was achieved in 24 out of 45 patients (53%). Cystectomy was performed in patients without complete response to transurethral resection and chemotherapy. The therapy was completed as planned in 45/47 patients. After transurethral resection, chemotherapy, and radiation therapy, biopsy proven complete response was achieved in 62% (28/45); Stage T2T3 in 67% (23/34), Stage T4 in 45% (5/11) of patients. Among 19 patients with positive biopsy findings after transurethral resection and chemotherapy, 14 underwent cystectomy. After follow-up of 4-55 months (median 23 months) 75% (34/45) are alive, 68% (31/45) have had their bladders preserved, and 53% (24/45) are free of the primary tumor. The actuarial survival of all 45 patients is 73%. Moderate nausea and vomiting during treatment were common; severe leukopenia and mucositis were observed in five patients. Late side effects such as miction disorders and diarrhea were predominantly mild. Although the observation period has been too short to allow a definitive evaluation of treatment results, we feel both from the point of bladder preservation and disease-free survival that the presented treatment approach is successful in a majority of T2T3 patients, whereas a large tumor size (T4) renders this treatment less effective." @default.
- W2034305770 created "2016-06-24" @default.
- W2034305770 creator A5005641529 @default.
- W2034305770 creator A5059795069 @default.
- W2034305770 creator A5080808621 @default.
- W2034305770 creator A5081094525 @default.
- W2034305770 creator A5082325043 @default.
- W2034305770 date "1993-04-01" @default.
- W2034305770 modified "2023-09-27" @default.
- W2034305770 title "Sequential transurethral surgery, multiple drug chemotherapy and radiation therapy for invasive bladder carcinoma: Initial report" @default.
- W2034305770 cites W2006591192 @default.
- W2034305770 cites W2011803401 @default.
- W2034305770 cites W2037862689 @default.
- W2034305770 cites W2071772756 @default.
- W2034305770 cites W2142981756 @default.
- W2034305770 cites W2486390096 @default.
- W2034305770 cites W4235826954 @default.
- W2034305770 cites W4239330499 @default.
- W2034305770 cites W4293241248 @default.
- W2034305770 doi "https://doi.org/10.1016/0360-3016(93)90305-f" @default.
- W2034305770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8478227" @default.
- W2034305770 hasPublicationYear "1993" @default.
- W2034305770 type Work @default.
- W2034305770 sameAs 2034305770 @default.
- W2034305770 citedByCount "22" @default.
- W2034305770 countsByYear W20343057702012 @default.
- W2034305770 countsByYear W20343057702016 @default.
- W2034305770 crossrefType "journal-article" @default.
- W2034305770 hasAuthorship W2034305770A5005641529 @default.
- W2034305770 hasAuthorship W2034305770A5059795069 @default.
- W2034305770 hasAuthorship W2034305770A5080808621 @default.
- W2034305770 hasAuthorship W2034305770A5081094525 @default.
- W2034305770 hasAuthorship W2034305770A5082325043 @default.
- W2034305770 hasConcept C121608353 @default.
- W2034305770 hasConcept C126322002 @default.
- W2034305770 hasConcept C126894567 @default.
- W2034305770 hasConcept C141071460 @default.
- W2034305770 hasConcept C2775910329 @default.
- W2034305770 hasConcept C2776694085 @default.
- W2034305770 hasConcept C2777132456 @default.
- W2034305770 hasConcept C2778769751 @default.
- W2034305770 hasConcept C2779762690 @default.
- W2034305770 hasConcept C2780352672 @default.
- W2034305770 hasConcept C2780873365 @default.
- W2034305770 hasConcept C509974204 @default.
- W2034305770 hasConcept C71924100 @default.
- W2034305770 hasConcept C77411442 @default.
- W2034305770 hasConceptScore W2034305770C121608353 @default.
- W2034305770 hasConceptScore W2034305770C126322002 @default.
- W2034305770 hasConceptScore W2034305770C126894567 @default.
- W2034305770 hasConceptScore W2034305770C141071460 @default.
- W2034305770 hasConceptScore W2034305770C2775910329 @default.
- W2034305770 hasConceptScore W2034305770C2776694085 @default.
- W2034305770 hasConceptScore W2034305770C2777132456 @default.
- W2034305770 hasConceptScore W2034305770C2778769751 @default.
- W2034305770 hasConceptScore W2034305770C2779762690 @default.
- W2034305770 hasConceptScore W2034305770C2780352672 @default.
- W2034305770 hasConceptScore W2034305770C2780873365 @default.
- W2034305770 hasConceptScore W2034305770C509974204 @default.
- W2034305770 hasConceptScore W2034305770C71924100 @default.
- W2034305770 hasConceptScore W2034305770C77411442 @default.
- W2034305770 hasIssue "5" @default.
- W2034305770 hasLocation W20343057701 @default.
- W2034305770 hasLocation W20343057702 @default.
- W2034305770 hasOpenAccess W2034305770 @default.
- W2034305770 hasPrimaryLocation W20343057701 @default.
- W2034305770 hasRelatedWork W1036257620 @default.
- W2034305770 hasRelatedWork W18081430 @default.
- W2034305770 hasRelatedWork W1988588677 @default.
- W2034305770 hasRelatedWork W2016339089 @default.
- W2034305770 hasRelatedWork W2120561004 @default.
- W2034305770 hasRelatedWork W2138050084 @default.
- W2034305770 hasRelatedWork W2433727248 @default.
- W2034305770 hasRelatedWork W2614838328 @default.
- W2034305770 hasRelatedWork W3134279723 @default.
- W2034305770 hasRelatedWork W4251563109 @default.
- W2034305770 hasVolume "25" @default.
- W2034305770 isParatext "false" @default.
- W2034305770 isRetracted "false" @default.
- W2034305770 magId "2034305770" @default.
- W2034305770 workType "article" @default.