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- W2034307870 abstract "Abstract 1. 1. The oligomycin-like effect of biguanide derivatives, which was reported previously, has been investigated in more detail. 2. 2. Phenethylbiguanide, when used at high concentrations, not only inhibits succinate respiration but also DPNH-linked respiration in tightly coupled mitochondria. 3. 3. Evidence is given that aliphatic biguanides, which are inhibitors of energy transfer, may also act as uncoupling agents. Their coupling efficiency increases with the unpolar qualities of the molecule. n -Heptylbiguanie behaves as an uncoupler of the second phosphorylating site, whereas it is an inhibitor of the first. 4. 4. The inhibiting effects of biguanides occur after a short lag-period and the action of biguanide is highly dependent on the metabolic state of the mitochondria." @default.
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- W2034307870 date "1964-11-08" @default.
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- W2034307870 title "SITE-SPECIFIC UNCOUPLING AND INHIBITION OF ENERGY TRANSFER BY BIGUANIDES." @default.
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