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- W2034309293 abstract "(S)-3-(5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile is a potassium-channel opener developed for the treatment of urinary urge incontinence. The key step in the synthesis is an unsymmetrical Hantzsch reaction to give a 2-hydroxy-1,2,3,4-tetrahydropyridine. In our study the order of addition of reagents was found to be critical in the optimisation of the yield and the control of impurity levels in this reaction. The yield and the relative charges of the reagents were further optimised by the use of factorial experimental design. The chemistry has been scaled up to plant scale to produce multikilogram amounts of the Hantzsch product in close to 60% yield." @default.
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- W2034309293 date "2006-05-19" @default.
- W2034309293 modified "2023-10-18" @default.
- W2034309293 title "Development and Optimisation of an Unsymmetrical Hantzsch Reaction for Plant-Scale Manufacture" @default.
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- W2034309293 doi "https://doi.org/10.1021/op060057r" @default.
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