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- W2034309396 abstract "The 3A9 transgenic mouse line carries the rearranged TCR genes from a T cell hybridoma that recognizes hen egg lysozyme peptide 46-61 in the context of MHC class II Ak molecules. As expected, positive selection of immature 3A9 thymocytes to become mature CD4+ 8- T cells was efficient on the selecting CBA (H-2k) genetic background but not on the non-selecting C57BL/6 (H-2b) background. Surprisingly, positive selection was also inefficient on the CBA x C57BL/6 F1 background (H-2kb). We present evidence that expression of A(beta)b molecules on thymus epithelium (in conjunction with A(alpha)b or A(alpha)k molecules) inhibits the positive selection of 3A9 thymocytes mediated by A(alpha)k:A(beta)k complexes, in a process evocative of peptide antagonism of mature T cells." @default.
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- W2034309396 date "1999-02-01" @default.
- W2034309396 modified "2023-09-25" @default.
- W2034309396 title "Inhibition of thymocyte positive selection by natural MHC: peptide ligands" @default.
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- W2034309396 doi "https://doi.org/10.1002/(sici)1521-4141(199902)29:02<394::aid-immu394>3.0.co;2-2" @default.
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