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• W2034309923 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2003Orthotopic Urinary Diversion After Cystectomy For Bladder Cancer: Implications For Cancer Control And Patterns Of Disease Recurrence OFER YOSSEPOWITCH, GUIDO DALBAGNI, DRAGAN GOLIJANIN, S. MACHELE DONAT, BERNARD H. BOCHNER, HARRY W. HERR, WILLIAM R. FAIR, and PAUL RUSSO OFER YOSSEPOWITCHOFER YOSSEPOWITCH More articles by this author , GUIDO DALBAGNIGUIDO DALBAGNI More articles by this author , DRAGAN GOLIJANINDRAGAN GOLIJANIN More articles by this author , S. MACHELE DONATS. MACHELE DONAT More articles by this author , BERNARD H. BOCHNERBERNARD H. BOCHNER More articles by this author , HARRY W. HERRHARRY W. HERR More articles by this author , WILLIAM R. FAIRWILLIAM R. FAIR More articles by this author , and PAUL RUSSOPAUL RUSSO More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64062-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The impact of orthotopic urinary diversion on the quality of cystectomy and ensuing cancer control has not been adequately studied. We analyzed our experience with this clinical problem. Materials and Methods: The records of 214 patients who underwent cystectomy and orthotopic diversion for bladder cancer were retrospectively evaluated and compared with those of 269 treated with an ileal conduit. Analyzed end points included overall and cancer specific survival. We specifically assessed the patterns of relapse and their association with pathological findings at cystectomy in the neobladder group. Results: No cancer specific survival difference was identified in the neobladder and ileal conduit cohorts when adjusting for pathological stage. Patterns of relapse in 62 of the 214 patients with a neobladder (29%) included local recurrence in 23 (11%), distant recurrence in 19 (9%), and combined local and distant recurrence in 18 (8%). Urethral recurrence was rare (2%). Of 10 patients (4.6%) diagnosed with upper tract recurrence 6 and 4 initially had relapse in the ureteroenteric anastomosis and renal pelvis, respectively. Five of the 6 patients with anastomotic relapse had evidence of disease in the intramural or juxtavesical ureter that was removed en bloc with the cystectomy specimen. Only 1 patient required neobladder takedown after such anastomotic recurrence. Conclusions: These results indicate that neobladders do not compromise the quality of preceding cystectomy or interfere with management in the presence of local or distant disease relapse. 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Gschwend J (2003) Bladder substitutionCurrent Opinion in Urology, 10.1097/00042307-200311000-00010, VOL. 13, NO. 6, (477-482), Online publication date: 1-Nov-2003. Bochner B, Montie J and Lee C (2003) Follow-up strategies and management of recurrence in urologic oncology bladder cancer:Urologic Clinics of North America, 10.1016/S0094-0143(03)00061-2, VOL. 30, NO. 4, (777-789), Online publication date: 1-Nov-2003. Borden, L, Clark P and Hall M (2003) Bladder cancerCurrent Opinion in Oncology, 10.1097/00001622-200305000-00009, VOL. 15, NO. 3, (227-233), Online publication date: 1-May-2003. Volume 169Issue 1January 2003Page: 177-181 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsbladder neoplasmsneoplasm recurrence, localcystectomyurinary diversionileumMetrics Author Information OFER YOSSEPOWITCH More articles by this author GUIDO DALBAGNI More articles by this author DRAGAN GOLIJANIN More articles by this author S. MACHELE DONAT More articles by this author BERNARD H. BOCHNER More articles by this author HARRY W. HERR More articles by this author WILLIAM R. FAIR More articles by this author PAUL RUSSO More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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