Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034310303> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2034310303 endingPage "996" @default.
- W2034310303 startingPage "990" @default.
- W2034310303 abstract "Background: Adequate pharmacologic cardiac support in acute myocardial infarction (MI), as well as in chronic MI patients under β-blocker therapy, is problematic due to the impaired cardiac response to β-adrenergic agonists. New therapeutic approaches could resolve this problem. Istaroxime (ISTA) is a new Na+,K+-ATPase inhibitor and SERCA2 agonist. Aims: To evaluate: 1) the effects of dobutamine (DOB) on left ventricular function in early (48–72 h) and late (14 days) phases of a post-MI canine model, compared to ISTA, and 2) the efficacy of DOB in chronic left ventricular dysfunction (6 months post-MI) in dogs pre-treated or not with a β-blocker, compared with ISTA and milrinone (MIL). Results: When compared to the effects in healthy animals, DOB increased contractility only slightly in the first 48–72 h post-MI, whereas its efficacy recovered partially by day 14 and fully by 6 months after MI. ISTA had a greater effect on contractility than DOB and improved relaxation, while DOB did not. Moreover, β-adrenergic blockade inhibited the inotropic action of DOB, without altering the effect of ISTA. Surprisingly, ß-adrenergic blockade blunted the effects of MIL. Conclusion: ISTA may represent a novel strategy for enhancing left ventricular performance even in the context of acute MI and/or concomitant β-adrenergic blockade." @default.
- W2034310303 created "2016-06-24" @default.
- W2034310303 creator A5021965264 @default.
- W2034310303 creator A5045815002 @default.
- W2034310303 creator A5049912464 @default.
- W2034310303 creator A5051424966 @default.
- W2034310303 creator A5051880544 @default.
- W2034310303 creator A5053478512 @default.
- W2034310303 date "2008-10-01" @default.
- W2034310303 modified "2023-09-24" @default.
- W2034310303 title "Sympathomimetic inefficiency in restoring contractility in the acute or chronic β-blocker-treated ischaemic heart: Comparison with a new agent" @default.
- W2034310303 cites W2016449014 @default.
- W2034310303 cites W2030912486 @default.
- W2034310303 cites W2034315036 @default.
- W2034310303 cites W2039768299 @default.
- W2034310303 cites W2044030399 @default.
- W2034310303 cites W2046981197 @default.
- W2034310303 cites W2070875326 @default.
- W2034310303 cites W2097149135 @default.
- W2034310303 cites W2117947535 @default.
- W2034310303 cites W2147063144 @default.
- W2034310303 cites W2164188631 @default.
- W2034310303 cites W2229384143 @default.
- W2034310303 cites W2312437912 @default.
- W2034310303 cites W2319534362 @default.
- W2034310303 cites W2415141591 @default.
- W2034310303 doi "https://doi.org/10.1016/j.ejheart.2008.07.007" @default.
- W2034310303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18693136" @default.
- W2034310303 hasPublicationYear "2008" @default.
- W2034310303 type Work @default.
- W2034310303 sameAs 2034310303 @default.
- W2034310303 citedByCount "6" @default.
- W2034310303 countsByYear W20343103032012 @default.
- W2034310303 countsByYear W20343103032014 @default.
- W2034310303 countsByYear W20343103032017 @default.
- W2034310303 countsByYear W20343103032018 @default.
- W2034310303 crossrefType "journal-article" @default.
- W2034310303 hasAuthorship W2034310303A5021965264 @default.
- W2034310303 hasAuthorship W2034310303A5045815002 @default.
- W2034310303 hasAuthorship W2034310303A5049912464 @default.
- W2034310303 hasAuthorship W2034310303A5051424966 @default.
- W2034310303 hasAuthorship W2034310303A5051880544 @default.
- W2034310303 hasAuthorship W2034310303A5053478512 @default.
- W2034310303 hasConcept C126322002 @default.
- W2034310303 hasConcept C155710745 @default.
- W2034310303 hasConcept C164705383 @default.
- W2034310303 hasConcept C170493617 @default.
- W2034310303 hasConcept C178853913 @default.
- W2034310303 hasConcept C2776645727 @default.
- W2034310303 hasConcept C2778198053 @default.
- W2034310303 hasConcept C2778468042 @default.
- W2034310303 hasConcept C2781185063 @default.
- W2034310303 hasConcept C39133596 @default.
- W2034310303 hasConcept C500558357 @default.
- W2034310303 hasConcept C71924100 @default.
- W2034310303 hasConceptScore W2034310303C126322002 @default.
- W2034310303 hasConceptScore W2034310303C155710745 @default.
- W2034310303 hasConceptScore W2034310303C164705383 @default.
- W2034310303 hasConceptScore W2034310303C170493617 @default.
- W2034310303 hasConceptScore W2034310303C178853913 @default.
- W2034310303 hasConceptScore W2034310303C2776645727 @default.
- W2034310303 hasConceptScore W2034310303C2778198053 @default.
- W2034310303 hasConceptScore W2034310303C2778468042 @default.
- W2034310303 hasConceptScore W2034310303C2781185063 @default.
- W2034310303 hasConceptScore W2034310303C39133596 @default.
- W2034310303 hasConceptScore W2034310303C500558357 @default.
- W2034310303 hasConceptScore W2034310303C71924100 @default.
- W2034310303 hasIssue "10" @default.
- W2034310303 hasLocation W20343103031 @default.
- W2034310303 hasLocation W20343103032 @default.
- W2034310303 hasLocation W20343103033 @default.
- W2034310303 hasLocation W20343103034 @default.
- W2034310303 hasOpenAccess W2034310303 @default.
- W2034310303 hasPrimaryLocation W20343103031 @default.
- W2034310303 hasRelatedWork W1965987256 @default.
- W2034310303 hasRelatedWork W2036147767 @default.
- W2034310303 hasRelatedWork W2115713469 @default.
- W2034310303 hasRelatedWork W2133041246 @default.
- W2034310303 hasRelatedWork W2135619337 @default.
- W2034310303 hasRelatedWork W2318288688 @default.
- W2034310303 hasRelatedWork W3040480359 @default.
- W2034310303 hasRelatedWork W4225423590 @default.
- W2034310303 hasRelatedWork W4286310440 @default.
- W2034310303 hasRelatedWork W2065185224 @default.
- W2034310303 hasVolume "10" @default.
- W2034310303 isParatext "false" @default.
- W2034310303 isRetracted "false" @default.
- W2034310303 magId "2034310303" @default.
- W2034310303 workType "article" @default.