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• W2034320724 abstract "We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two 2-nitroimidazole moieties as exogenous hypoxia markers that undergo bioreductive activation and then selective entrapment in hypoxic cells. After treatment with GPU-167, tumor cells contained significantly higher levels of fluorescence in hypoxia than in normoxia. In vivo fluorescence imaging specifically detected GPU-167 in tumors 24 h after administration. Ex vivo analysis revealed that fluorescence showed a strong correlation with hypoxia inducible factor (HIF)-1 active hypoxic regions. These data suggest that GPU-167 is a promising in vivo optical imaging probe for tumor hypoxia." @default.
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• W2034320724 date "2012-02-22" @default.
• W2034320724 modified "2023-09-27" @default.
• W2034320724 title "2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for <i>in Vivo</i> Imaging of Tumor Hypoxia" @default.
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• W2034320724 doi "https://doi.org/10.1021/bc2004704" @default.
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