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- W2034320788 abstract "ABSTRACT Many postmenopausal women with advanced or metastatic breast cancer (BC) receive nonsteroidal aromatase inhibitors (NSAIs). Virtually all of them experience progression, but may still gain benefit from a different endocrine or targeted agent. We indirectly compare the results of trials on endocrine or targeted treatment in HR + /HER2 - mBC patients who progressed after a prior NSAI therapy. Although with the limitations of any indirect comparison, evidence suggests that only the combination of everolimus and exemestane is associated with a prolonged progression-free survival and a more evident clinical benefit than its comparators. We speculate that prior NSAI therapy can ‘per se’ individuate patients eligible to everolimus. More robust data from head-to-head trials will provide more grounded evidence on this issue." @default.
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- W2034320788 date "2015-03-01" @default.
- W2034320788 modified "2023-09-23" @default.
- W2034320788 title "Treatment options in HR+/HER2- advanced breast cancer patients pretreated with nonsteroidal aromatase inhibitors: what does current evidence tell us?" @default.
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- W2034320788 doi "https://doi.org/10.2217/fon.14.245" @default.
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