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- W2034321828 endingPage "581" @default.
- W2034321828 startingPage "574" @default.
- W2034321828 abstract "In voltage-gated ion channels, transmembrane segments S3 and S4 are involved in voltage sensing and adopt a helix-turn-helix conformation, called the paddle motif, in crystal structures. Now extensive mutagenesis and electrophysiology analyses of the Shaker K+ channel demonstrate the physiological relevance of the paddle motif and dissect the roles of each segment in voltage sensing. Voltage-gated ion channels underlie rapid electric signaling in excitable cells. Electrophysiological studies have established that the N-terminal half of the fourth transmembrane segment (NTS4) of these channels is the primary voltage sensor, whereas crystallographic studies have shown that NTS4 is not located within a proteinaceous pore. Rather, NTS4 and the C-terminal half of S3 (CTS3 or S3b) form a helix-turn-helix motif, termed the voltage-sensor paddle. This unexpected structural finding raises two fundamental questions: does the paddle motif also exist in voltage-gated channels in a biological membrane, and, if so, what is its function in voltage gating? Here, we provide evidence that the paddle motif exists in the open state of Drosophila Shaker voltage-gated K+ channels expressed in Xenopus oocytes and that CTS3 acts as an extracellular hydrophobic 'stabilizer' for NTS4, thus biasing the gating chemical equilibrium toward the open state." @default.
- W2034321828 created "2016-06-24" @default.
- W2034321828 creator A5014458771 @default.
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- W2034321828 creator A5031478799 @default.
- W2034321828 creator A5037300357 @default.
- W2034321828 creator A5041904342 @default.
- W2034321828 date "2013-03-31" @default.
- W2034321828 modified "2023-10-16" @default.
- W2034321828 title "Energetic role of the paddle motif in voltage gating of Shaker K+ channels" @default.
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- W2034321828 doi "https://doi.org/10.1038/nsmb.2535" @default.
- W2034321828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3777420" @default.
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- W2034321828 hasPublicationYear "2013" @default.
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