Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034329447> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2034329447 abstract "(1) Treatment with doxycyline substantially reduces the acute toxicity of daunomycin to the mouse. Treatment with doxycycline alters the distribution of daunomycin amongst the body tissues of the mouse. The ability of the isolated kidney to bind the daunomycin is enhanced by pretreatment with doxycycline. This observation is in agreement with the phenomenon noted in vivo with the same organ. (2) The antineoplastic activity of daunomycin, tested in vivo in mice bearing Sarcoma 180 is not modified by treatment with doxycyctine, nor does doxycycline modify the inhibition of DNA synthesis in isolated Sarcoma 180 cells by daunomycin. (3) The experiments carried out on isolated cell, namely: (a) lack of interactions between daunomycin and doxycycline on the incorporation of thymidine into DNA, (b) no modifications in the uptake and retention of daunomycin by cells pretreated with doxycyline, suggest the hypothesis that the similar pharmacological behavior of the two molecules with regard to the tumor is due to 2 kinds of receptors that are affected differently by the two drugs. (4) The decrease in the acute toxicity of the antibiastic drug might be due to an interaction between doxycycline and those receptors of the toxic effect which are normally affected by daunomycin in the animals not treated with doxycycline." @default.
- W2034329447 created "2016-06-24" @default.
- W2034329447 creator A5012952560 @default.
- W2034329447 creator A5023544659 @default.
- W2034329447 creator A5034393372 @default.
- W2034329447 creator A5050289046 @default.
- W2034329447 creator A5053391098 @default.
- W2034329447 creator A5089651756 @default.
- W2034329447 date "1973-01-01" @default.
- W2034329447 modified "2023-10-05" @default.
- W2034329447 title "INFLUENCE OF α-6-DEOXY-5-OXYTETRACYCLINE ON SOME PHARMA-COLOGICAL CHARACTERISTICS OF DAUNOMYCIN" @default.
- W2034329447 cites W17405798 @default.
- W2034329447 cites W2405190897 @default.
- W2034329447 doi "https://doi.org/10.7164/antibiotics.26.339" @default.
- W2034329447 hasPublicationYear "1973" @default.
- W2034329447 type Work @default.
- W2034329447 sameAs 2034329447 @default.
- W2034329447 citedByCount "0" @default.
- W2034329447 crossrefType "journal-article" @default.
- W2034329447 hasAuthorship W2034329447A5012952560 @default.
- W2034329447 hasAuthorship W2034329447A5023544659 @default.
- W2034329447 hasAuthorship W2034329447A5034393372 @default.
- W2034329447 hasAuthorship W2034329447A5050289046 @default.
- W2034329447 hasAuthorship W2034329447A5053391098 @default.
- W2034329447 hasAuthorship W2034329447A5089651756 @default.
- W2034329447 hasBestOaLocation W20343294471 @default.
- W2034329447 hasConcept C116263406 @default.
- W2034329447 hasConcept C150903083 @default.
- W2034329447 hasConcept C178790620 @default.
- W2034329447 hasConcept C185592680 @default.
- W2034329447 hasConcept C202751555 @default.
- W2034329447 hasConcept C207001950 @default.
- W2034329447 hasConcept C2777179404 @default.
- W2034329447 hasConcept C29730261 @default.
- W2034329447 hasConcept C501593827 @default.
- W2034329447 hasConcept C55493867 @default.
- W2034329447 hasConcept C86803240 @default.
- W2034329447 hasConcept C98274493 @default.
- W2034329447 hasConceptScore W2034329447C116263406 @default.
- W2034329447 hasConceptScore W2034329447C150903083 @default.
- W2034329447 hasConceptScore W2034329447C178790620 @default.
- W2034329447 hasConceptScore W2034329447C185592680 @default.
- W2034329447 hasConceptScore W2034329447C202751555 @default.
- W2034329447 hasConceptScore W2034329447C207001950 @default.
- W2034329447 hasConceptScore W2034329447C2777179404 @default.
- W2034329447 hasConceptScore W2034329447C29730261 @default.
- W2034329447 hasConceptScore W2034329447C501593827 @default.
- W2034329447 hasConceptScore W2034329447C55493867 @default.
- W2034329447 hasConceptScore W2034329447C86803240 @default.
- W2034329447 hasConceptScore W2034329447C98274493 @default.
- W2034329447 hasLocation W20343294471 @default.
- W2034329447 hasOpenAccess W2034329447 @default.
- W2034329447 hasPrimaryLocation W20343294471 @default.
- W2034329447 hasRelatedWork W1606041119 @default.
- W2034329447 hasRelatedWork W1984643645 @default.
- W2034329447 hasRelatedWork W1996963783 @default.
- W2034329447 hasRelatedWork W2016541628 @default.
- W2034329447 hasRelatedWork W2043750034 @default.
- W2034329447 hasRelatedWork W2087937626 @default.
- W2034329447 hasRelatedWork W2096188315 @default.
- W2034329447 hasRelatedWork W2101737376 @default.
- W2034329447 hasRelatedWork W2114171825 @default.
- W2034329447 hasRelatedWork W2131283629 @default.
- W2034329447 hasRelatedWork W2397842015 @default.
- W2034329447 hasRelatedWork W2402468157 @default.
- W2034329447 hasRelatedWork W2409651531 @default.
- W2034329447 hasRelatedWork W2410811764 @default.
- W2034329447 hasRelatedWork W2413553926 @default.
- W2034329447 hasRelatedWork W2413898178 @default.
- W2034329447 hasRelatedWork W2465261289 @default.
- W2034329447 hasRelatedWork W2591526867 @default.
- W2034329447 hasRelatedWork W65947315 @default.
- W2034329447 hasRelatedWork W2533110151 @default.
- W2034329447 isParatext "false" @default.
- W2034329447 isRetracted "false" @default.
- W2034329447 magId "2034329447" @default.
- W2034329447 workType "article" @default.