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• W2034330235 startingPage "4323" @default.
• W2034330235 abstract "Hemorrhage remains a leading cause of early death after trauma, and infectious complications in combat wounds continue to challenge caregivers. Although chitosan dressings have been developed to address these problems, they are not always effective in controlling bleeding or killing bacteria. We aimed to refine the chitosan dressing by incorporating a procoagulant (polyphosphate) and an antimicrobial (silver). Chitosan containing different amounts and types of polyphosphate polymers was fabricated, and their hemostatic efficacies evaluated in vitro. The optimal chitosan-polyphosphate formulation (ChiPP) accelerated blood clotting (p = 0.011), increased platelet adhesion (p = 0.002), generated thrombin faster (p = 0.002), and absorbed more blood than chitosan (p < 0.001). Silver-loaded ChiPP exhibited significantly greater bactericidal activity than ChiPP in vitro, achieving a complete kill of Pseudomonas aeruginosa and a >99.99% kill of Staphylococcus aureus consistently. The silver dressing also significantly reduced mortality from 90% to 14.3% in a P. aeruginosa wound infection model in mice. Although the dressing exerted severe cytotoxicity against cultured fibroblasts, wound healing was not inhibited. This study demonstrated for the first time, the application of polyphosphate as a hemostatic adjuvant, and developed a new chitosan-based composite with potent hemostatic and antimicrobial properties." @default.
• W2034330235 created "2016-06-24" @default.
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• W2034330235 date "2008-11-01" @default.
• W2034330235 modified "2023-10-10" @default.
• W2034330235 title "Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties" @default.
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• W2034330235 doi "https://doi.org/10.1016/j.biomaterials.2008.07.034" @default.
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