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• W2034332279 abstract "Moth pheromones cause rises in intracellular Ca 2+ concentrations that activate Ca 2+ -dependent cation channels in antennal olfactory receptor neurons. In addition, mechanisms of adaptation and sensitization depend on changes in cyclic nucleotide concentrations. Here, cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the moth Manduca sexta are described, which share properties with currents through vertebrate cyclic nucleotide-gated channels. The cyclic nucleotide-activated currents of M. sexta carried Ca 2+ and monovalent cations. They were directly activated by cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), modulated by Ca 2+ /calmodulin, and inhibited by lanthanum. M. sexta cyclic nucleotide-activated currents developed in an all-or-none manner, which suggests that the underlying channels are coupled and act coordinately. At least one cAMP- and two cGMP-activated nonselective cation currents could be distinguished. Compared with the cAMP-activated current, both cGMP-activated currents appeared to conduct more Ca 2+ and showed a stronger down-regulation by Ca 2+ /calmodulin-dependent negative feedback. Furthermore, both cGMP-activated currents differed in their Ca 2+ -dependent inhibition. Thus M. sexta olfactory receptor neurons, like vertebrate sensory neurons, appear to express nonselective cyclic nucleotide-activated cation channels with different subunit compositions. Besides the nonselective cyclic nucleotide-activated cation currents, olfactory receptor neurons express a cAMP-dependent current. This current resembled a protein kinase-modulated low-voltage–activated Ca 2+ current." @default.
• W2034332279 created "2016-06-24" @default.
• W2034332279 creator A5031145274 @default.
• W2034332279 creator A5083011986 @default.
• W2034332279 date "2008-11-01" @default.
• W2034332279 modified "2023-09-23" @default.
• W2034332279 title "Cyclic Nucleotide-Activated Currents in Cultured Olfactory Receptor Neurons of the Hawkmoth<i>Manduca sexta</i>" @default.
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• W2034332279 doi "https://doi.org/10.1152/jn.01400.2007" @default.
• W2034332279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18684910" @default.
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