Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034332670> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2034332670 abstract "Abstract In rats the pharmacokinetic interactions between the anticholinergic drug biperiden and [3H]quinuclidinyl benzylate ([3H]QNB) or [3H]N-methylscopolamine ([3H]NMS) is affected by the sequence in which the drugs are administered. Drug concentrations in various tissues were determined after intravenous administration of [3H]QNB or [3H]NMS (325 ng kg−1). Biperiden (6.4 mg kg−1) was administered either 5 min before, concomitantly with or 20 min after injection of [3H]QNB or [3H]NMS. When biperiden was administered concomitantly with or before [3H]QNB, distribution of [3H]QNB among the regions of the brain and other tissues was reduced; at 4 h the ratio of the distribution of [3H]QNB for experimental animals to that for control animals ranged from 0.15 to 0.9. When biperiden was administered after [3H]QNB, the distribution of [3H]QNB in the brain and other tissues was significantly higher than for the other two treatments (P < 0.01). However, for [3H]NMS the sequence of administration had no effect on the distribution of the drug in the brain and other tissues except for the kidney. In-vitro, in crude synaptosomal membranes, the amount of [3H]QNB at 2 h relative to the control concentration at equilibrium was 87% when biperiden was added before [3H]QNB and 56% when biperiden was added after [3H]QNB. In both instances the concentration of [3H]NMS reached equilibrium within 30 min. These findings suggest that the difference between the rate constant of association and dissociation at the possible site of action gives rise to the effect of the sequence of administration on the pharmacokinetic interaction." @default.
- W2034332670 created "2016-06-24" @default.
- W2034332670 creator A5004385323 @default.
- W2034332670 creator A5005873349 @default.
- W2034332670 creator A5026410489 @default.
- W2034332670 creator A5044426652 @default.
- W2034332670 creator A5083685473 @default.
- W2034332670 creator A5088876288 @default.
- W2034332670 date "1998-02-01" @default.
- W2034332670 modified "2023-10-14" @default.
- W2034332670 title "Effect of Sequence of Administration on the Pharmacokinetic In,t. eraction between the Anticholinergic n Drug Biperiden and ['H]Quinuclidinyl Benzylate or [5H]N-Methylscopolamine in Rats" @default.
- W2034332670 cites W1520754068 @default.
- W2034332670 cites W1987401576 @default.
- W2034332670 cites W1989582849 @default.
- W2034332670 cites W1998776530 @default.
- W2034332670 cites W2007788870 @default.
- W2034332670 cites W2052625909 @default.
- W2034332670 cites W2087526401 @default.
- W2034332670 cites W2089657331 @default.
- W2034332670 cites W2095572383 @default.
- W2034332670 cites W2115250531 @default.
- W2034332670 cites W2170223225 @default.
- W2034332670 doi "https://doi.org/10.1111/j.2042-7158.1998.tb06175.x" @default.
- W2034332670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9530987" @default.
- W2034332670 hasPublicationYear "1998" @default.
- W2034332670 type Work @default.
- W2034332670 sameAs 2034332670 @default.
- W2034332670 citedByCount "1" @default.
- W2034332670 crossrefType "journal-article" @default.
- W2034332670 hasAuthorship W2034332670A5004385323 @default.
- W2034332670 hasAuthorship W2034332670A5005873349 @default.
- W2034332670 hasAuthorship W2034332670A5026410489 @default.
- W2034332670 hasAuthorship W2034332670A5044426652 @default.
- W2034332670 hasAuthorship W2034332670A5083685473 @default.
- W2034332670 hasAuthorship W2034332670A5088876288 @default.
- W2034332670 hasConcept C110121322 @default.
- W2034332670 hasConcept C112705442 @default.
- W2034332670 hasConcept C134306372 @default.
- W2034332670 hasConcept C170493617 @default.
- W2034332670 hasConcept C185592680 @default.
- W2034332670 hasConcept C2778689640 @default.
- W2034332670 hasConcept C2908651707 @default.
- W2034332670 hasConcept C33789571 @default.
- W2034332670 hasConcept C33923547 @default.
- W2034332670 hasConcept C42219234 @default.
- W2034332670 hasConcept C55493867 @default.
- W2034332670 hasConcept C71924100 @default.
- W2034332670 hasConcept C98274493 @default.
- W2034332670 hasConceptScore W2034332670C110121322 @default.
- W2034332670 hasConceptScore W2034332670C112705442 @default.
- W2034332670 hasConceptScore W2034332670C134306372 @default.
- W2034332670 hasConceptScore W2034332670C170493617 @default.
- W2034332670 hasConceptScore W2034332670C185592680 @default.
- W2034332670 hasConceptScore W2034332670C2778689640 @default.
- W2034332670 hasConceptScore W2034332670C2908651707 @default.
- W2034332670 hasConceptScore W2034332670C33789571 @default.
- W2034332670 hasConceptScore W2034332670C33923547 @default.
- W2034332670 hasConceptScore W2034332670C42219234 @default.
- W2034332670 hasConceptScore W2034332670C55493867 @default.
- W2034332670 hasConceptScore W2034332670C71924100 @default.
- W2034332670 hasConceptScore W2034332670C98274493 @default.
- W2034332670 hasLocation W20343326701 @default.
- W2034332670 hasLocation W20343326702 @default.
- W2034332670 hasOpenAccess W2034332670 @default.
- W2034332670 hasPrimaryLocation W20343326701 @default.
- W2034332670 hasRelatedWork W1964503998 @default.
- W2034332670 hasRelatedWork W1969876219 @default.
- W2034332670 hasRelatedWork W2035434638 @default.
- W2034332670 hasRelatedWork W2038782216 @default.
- W2034332670 hasRelatedWork W2049819497 @default.
- W2034332670 hasRelatedWork W2400461952 @default.
- W2034332670 hasRelatedWork W2744667494 @default.
- W2034332670 hasRelatedWork W2949239631 @default.
- W2034332670 hasRelatedWork W3024440267 @default.
- W2034332670 hasRelatedWork W4205993769 @default.
- W2034332670 isParatext "false" @default.
- W2034332670 isRetracted "false" @default.
- W2034332670 magId "2034332670" @default.
- W2034332670 workType "article" @default.