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- W2034334262 abstract "Peripherin, a neuronal intermediate filament protein associated with axonal spheroids in amyotrophic lateral sclerosis (ALS), induces the selective degeneration of motor neurons when overexpressed in transgenic mice. To further clarify the selectivity and mechanism of peripherin-induced neuronal death, we analyzed the effects of peripherin overexpression in primary neuronal cultures. Peripherin overexpression led to the formation of cytoplasmic protein aggregates and caused the death not only of motor neurons, but also of dorsal root ganglion (DRG) neurons that were cultured from dissociated spinal cords of peripherin transgenic embryos. Apoptosis of DRG neurons containing peripherin aggregates was dependent on the proinflammatory central nervous system environment of spinal cultures, rich in activated microglia, and required TNF-alpha. This synergistic proapoptotic effect may contribute to neuronal selectivity in ALS." @default.
- W2034334262 created "2016-06-24" @default.
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- W2034334262 creator A5058693559 @default.
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- W2034334262 date "2001-10-15" @default.
- W2034334262 modified "2023-09-25" @default.
- W2034334262 title "Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α" @default.
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- W2034334262 doi "https://doi.org/10.1083/jcb.200107058" @default.
- W2034334262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2198840" @default.
- W2034334262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11604419" @default.
- W2034334262 hasPublicationYear "2001" @default.
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