FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034337445> ?p ?o ?g. }

• W2034337445 endingPage "358" @default.
• W2034337445 startingPage "353" @default.
• W2034337445 abstract "In Brief Valerian is a medicinal herb that produces anxiolytic and sedative effects. It was suggested that valerian acts via gamma-aminobutyric acid (GABA)ergic mechanisms. Previous studies showed binding of valerian extract to GABA receptors, but the functional effect of the binding has not been demonstrated. In this study we evaluated the GABAergic effect of valerian extract and one of its major constituents, valerenic acid, on brainstem neuronal activity in an in vitro neonatal rat brainstem preparation. We first observed that muscimol, a GABAA receptor agonist, decreased the firing rate in most brainstem neurons in a concentration-related fashion; 30 μM produced a 38.9% ± 3.0% (mean ± se) inhibition compared with control values (P < 0.01; 50% inhibitory concentration [IC50], 2.0 ± 0.1 μM). This effect was antagonized by bicuculline (10 μM), a GABAA antagonist. Then we showed that valerian extract 3 mg/mL induced a 29.6% ± 5.1% inhibition with an IC50 of 240 ± 18.7 μg/mL, whereas 100 μM valerenic acid induced a 22.2% ± 3.4% inhibition with an IC50 of 23 ± 2.6 μM (both P < 0.01). Bicuculline antagonized the inhibitory effects of both the valerian extract and valerenic acid. In addition, pretreatment with valerian extract or valerenic acid decreased the brainstem inhibitory effects produced by muscimol (both P < 0.05), suggesting that these compounds play an important role in the regulation of GABAergic activity. Data from this study suggest that the pharmacological effects of valerian extract and valerenic acid are mediated through modulation of GABAA receptor function. Thus, valerian may potentiate the sedative effects of anesthetics and other medications that act on GABA receptors, and presurgical valerian use may cause a valerian-anesthetic interaction. IMPLICATIONS: Valerian is an herb used in treating anxiety and insomnia. We observed that the valerian effects are mediated through brain gamma-aminobutyric acid (GABA) receptors in a rat brainstem preparation. Thus, valerian may potentiate the effects of anesthetics that act on GABA receptors, and presurgical valerian use may cause a valerian-anesthetic interaction." @default.
• W2034337445 created "2016-06-24" @default.
• W2034337445 creator A5013676487 @default.
• W2034337445 creator A5020423570 @default.
• W2034337445 creator A5036361101 @default.
• W2034337445 creator A5057272358 @default.
• W2034337445 creator A5078109636 @default.
• W2034337445 creator A5091822752 @default.
• W2034337445 date "2004-02-01" @default.
• W2034337445 modified "2023-09-27" @default.
• W2034337445 title "The Gamma-Aminobutyric Acidergic Effects of Valerian and Valerenic Acid on Rat Brainstem Neuronal Activity" @default.
• W2034337445 cites W101923745 @default.
• W2034337445 cites W1969009804 @default.
• W2034337445 cites W1970863595 @default.
• W2034337445 cites W1977341729 @default.
• W2034337445 cites W1978782395 @default.
• W2034337445 cites W1983208188 @default.
• W2034337445 cites W1986069057 @default.
• W2034337445 cites W1987664358 @default.
• W2034337445 cites W2013817917 @default.
• W2034337445 cites W2021489551 @default.
• W2034337445 cites W2021619704 @default.
• W2034337445 cites W2023283569 @default.
• W2034337445 cites W2026280149 @default.
• W2034337445 cites W2026569432 @default.
• W2034337445 cites W2034067206 @default.
• W2034337445 cites W2047940614 @default.
• W2034337445 cites W2053936471 @default.
• W2034337445 cites W2057430670 @default.
• W2034337445 cites W2062530724 @default.
• W2034337445 cites W2076647901 @default.
• W2034337445 cites W2086203155 @default.
• W2034337445 cites W2093910293 @default.
• W2034337445 cites W2126079670 @default.
• W2034337445 cites W2165525801 @default.
• W2034337445 cites W2992271263 @default.
• W2034337445 cites W4233719326 @default.
• W2034337445 cites W4242294771 @default.
• W2034337445 cites W4251535289 @default.
• W2034337445 doi "https://doi.org/10.1213/01.ane.0000096189.70405.a5" @default.
• W2034337445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14742369" @default.
• W2034337445 hasPublicationYear "2004" @default.
• W2034337445 type Work @default.
• W2034337445 sameAs 2034337445 @default.
• W2034337445 citedByCount "105" @default.
• W2034337445 countsByYear W20343374452012 @default.
• W2034337445 countsByYear W20343374452013 @default.
• W2034337445 countsByYear W20343374452014 @default.
• W2034337445 countsByYear W20343374452015 @default.
• W2034337445 countsByYear W20343374452016 @default.
• W2034337445 countsByYear W20343374452017 @default.
• W2034337445 countsByYear W20343374452018 @default.
• W2034337445 countsByYear W20343374452019 @default.
• W2034337445 countsByYear W20343374452020 @default.
• W2034337445 countsByYear W20343374452021 @default.
• W2034337445 countsByYear W20343374452022 @default.
• W2034337445 countsByYear W20343374452023 @default.
• W2034337445 crossrefType "journal-article" @default.
• W2034337445 hasAuthorship W2034337445A5013676487 @default.
• W2034337445 hasAuthorship W2034337445A5020423570 @default.
• W2034337445 hasAuthorship W2034337445A5036361101 @default.
• W2034337445 hasAuthorship W2034337445A5057272358 @default.
• W2034337445 hasAuthorship W2034337445A5078109636 @default.
• W2034337445 hasAuthorship W2034337445A5091822752 @default.
• W2034337445 hasBestOaLocation W20343374451 @default.
• W2034337445 hasConcept C126322002 @default.
• W2034337445 hasConcept C168258287 @default.
• W2034337445 hasConcept C170493617 @default.
• W2034337445 hasConcept C17077164 @default.
• W2034337445 hasConcept C2777771985 @default.
• W2034337445 hasConcept C2777845490 @default.
• W2034337445 hasConcept C2778409475 @default.
• W2034337445 hasConcept C2779177108 @default.
• W2034337445 hasConcept C2779188335 @default.
• W2034337445 hasConcept C2780763569 @default.
• W2034337445 hasConcept C71924100 @default.
• W2034337445 hasConcept C98274493 @default.
• W2034337445 hasConceptScore W2034337445C126322002 @default.
• W2034337445 hasConceptScore W2034337445C168258287 @default.
• W2034337445 hasConceptScore W2034337445C170493617 @default.
• W2034337445 hasConceptScore W2034337445C17077164 @default.
• W2034337445 hasConceptScore W2034337445C2777771985 @default.
• W2034337445 hasConceptScore W2034337445C2777845490 @default.
• W2034337445 hasConceptScore W2034337445C2778409475 @default.
• W2034337445 hasConceptScore W2034337445C2779177108 @default.
• W2034337445 hasConceptScore W2034337445C2779188335 @default.
• W2034337445 hasConceptScore W2034337445C2780763569 @default.
• W2034337445 hasConceptScore W2034337445C71924100 @default.
• W2034337445 hasConceptScore W2034337445C98274493 @default.
• W2034337445 hasLocation W20343374451 @default.
• W2034337445 hasLocation W20343374452 @default.
• W2034337445 hasOpenAccess W2034337445 @default.
• W2034337445 hasPrimaryLocation W20343374451 @default.
• W2034337445 hasRelatedWork W1985658274 @default.
• W2034337445 hasRelatedWork W1991331973 @default.
• W2034337445 hasRelatedWork W1995906194 @default.
• W2034337445 hasRelatedWork W2018425356 @default.
• W2034337445 hasRelatedWork W2027040168 @default.

• next