FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034338005> ?p ?o ?g. }

• W2034338005 endingPage "3260" @default.
• W2034338005 startingPage "3256" @default.
• W2034338005 abstract "A new scaffold N-(9-(ortho/meta/para-(benzyloxy)phenyl)-3,3,6,6-tetramethyl-1,8-dioxo-1,2,3,4,5,6,7,8-octahydroacridin-10(9H)-yl) isonicotinamide (H1-3) was discovered as a hSIRT1 inhibitor through virtual screening of in-house database. Based on these hits, a library of compounds were designed, synthesized and tested for in vitro hSIRT1 activity. The most potent compound 4d in the series showed a significant inhibition of SIRT1 activity. Further antitumor studies of compound 4d, showed a dose dependent increase in acetylation of p53K382 and decrease in SIRT1 with an IC50 of 0.25 μM in MDA-MB231 breast cancer cell lines. Individual 3D-QSAR analysis using Schrödinger showed distribution of hydrophobic and non polar positive co-efficient at ortho position essential for bioactivity based on 4d." @default.
• W2034338005 created "2016-06-24" @default.
• W2034338005 creator A5034495853 @default.
• W2034338005 creator A5049801325 @default.
• W2034338005 creator A5053813413 @default.
• W2034338005 creator A5055370602 @default.
• W2034338005 creator A5070250598 @default.
• W2034338005 creator A5083522590 @default.
• W2034338005 creator A5085931640 @default.
• W2034338005 date "2012-05-01" @default.
• W2034338005 modified "2023-10-14" @default.
• W2034338005 title "Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies" @default.
• W2034338005 cites W1986191025 @default.
• W2034338005 cites W1990931780 @default.
• W2034338005 cites W1998533677 @default.
• W2034338005 cites W2001346869 @default.
• W2034338005 cites W2002934450 @default.
• W2034338005 cites W2005789183 @default.
• W2034338005 cites W2007326142 @default.
• W2034338005 cites W2012753961 @default.
• W2034338005 cites W2018048294 @default.
• W2034338005 cites W2029415122 @default.
• W2034338005 cites W2033307149 @default.
• W2034338005 cites W2043932983 @default.
• W2034338005 cites W2054447845 @default.
• W2034338005 cites W2057695983 @default.
• W2034338005 cites W2058768220 @default.
• W2034338005 cites W2072989310 @default.
• W2034338005 cites W2078673393 @default.
• W2034338005 cites W2078689410 @default.
• W2034338005 cites W2080626304 @default.
• W2034338005 cites W2084325219 @default.
• W2034338005 cites W2087841813 @default.
• W2034338005 cites W2088669944 @default.
• W2034338005 cites W2089112805 @default.
• W2034338005 cites W2091457094 @default.
• W2034338005 cites W2092507534 @default.
• W2034338005 cites W2093087462 @default.
• W2034338005 cites W2101690600 @default.
• W2034338005 cites W2102635586 @default.
• W2034338005 cites W2106715610 @default.
• W2034338005 cites W2111184587 @default.
• W2034338005 cites W2124595934 @default.
• W2034338005 cites W2149703257 @default.
• W2034338005 cites W2152101492 @default.
• W2034338005 cites W2157657345 @default.
• W2034338005 cites W2163159420 @default.
• W2034338005 doi "https://doi.org/10.1016/j.bmcl.2012.03.030" @default.
• W2034338005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22464458" @default.
• W2034338005 hasPublicationYear "2012" @default.
• W2034338005 type Work @default.
• W2034338005 sameAs 2034338005 @default.
• W2034338005 citedByCount "31" @default.
• W2034338005 countsByYear W20343380052012 @default.
• W2034338005 countsByYear W20343380052013 @default.
• W2034338005 countsByYear W20343380052014 @default.
• W2034338005 countsByYear W20343380052015 @default.
• W2034338005 countsByYear W20343380052016 @default.
• W2034338005 countsByYear W20343380052017 @default.
• W2034338005 countsByYear W20343380052018 @default.
• W2034338005 countsByYear W20343380052019 @default.
• W2034338005 countsByYear W20343380052020 @default.
• W2034338005 countsByYear W20343380052021 @default.
• W2034338005 countsByYear W20343380052022 @default.
• W2034338005 countsByYear W20343380052023 @default.
• W2034338005 crossrefType "journal-article" @default.
• W2034338005 hasAuthorship W2034338005A5034495853 @default.
• W2034338005 hasAuthorship W2034338005A5049801325 @default.
• W2034338005 hasAuthorship W2034338005A5053813413 @default.
• W2034338005 hasAuthorship W2034338005A5055370602 @default.
• W2034338005 hasAuthorship W2034338005A5070250598 @default.
• W2034338005 hasAuthorship W2034338005A5083522590 @default.
• W2034338005 hasAuthorship W2034338005A5085931640 @default.
• W2034338005 hasConcept C103697762 @default.
• W2034338005 hasConcept C104317684 @default.
• W2034338005 hasConcept C119157956 @default.
• W2034338005 hasConcept C181199279 @default.
• W2034338005 hasConcept C185592680 @default.
• W2034338005 hasConcept C193042331 @default.
• W2034338005 hasConcept C202751555 @default.
• W2034338005 hasConcept C21951064 @default.
• W2034338005 hasConcept C2777752112 @default.
• W2034338005 hasConcept C2777752497 @default.
• W2034338005 hasConcept C55493867 @default.
• W2034338005 hasConcept C56173144 @default.
• W2034338005 hasConcept C62112901 @default.
• W2034338005 hasConcept C71240020 @default.
• W2034338005 hasConceptScore W2034338005C103697762 @default.
• W2034338005 hasConceptScore W2034338005C104317684 @default.
• W2034338005 hasConceptScore W2034338005C119157956 @default.
• W2034338005 hasConceptScore W2034338005C181199279 @default.
• W2034338005 hasConceptScore W2034338005C185592680 @default.
• W2034338005 hasConceptScore W2034338005C193042331 @default.
• W2034338005 hasConceptScore W2034338005C202751555 @default.
• W2034338005 hasConceptScore W2034338005C21951064 @default.
• W2034338005 hasConceptScore W2034338005C2777752112 @default.
• W2034338005 hasConceptScore W2034338005C2777752497 @default.
• W2034338005 hasConceptScore W2034338005C55493867 @default.

• next