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• W2034340607 startingPage "1545" @default.
• W2034340607 abstract "Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however, its clinical relevance has not yet been established.Areas covered in this review: We herein review the contribution of NHE-1 in atherogenesis (namely its effect on endothelial cells, monocytes, smooth muscle cells and platelets).What the reader will gain: Studies have shown that NHE is involved in atherogenesis-related properties of isolated monocytes. We also consider the relationship between NHE-1 and vascular risk factors such as obesity, diabetes mellitus, hypertension, dyslipidemia and inflammation.Take home message: Even though clinical trials with certain NHE-1 inhibitors have had discouraging results, NHE-1 cannot be excluded as a potential future therapeutic target for the prevention and/or treatment of atherosclerosis." @default.
• W2034340607 created "2016-06-24" @default.
• W2034340607 creator A5011503247 @default.
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• W2034340607 creator A5071840160 @default.
• W2034340607 creator A5090081265 @default.
• W2034340607 creator A5091091971 @default.
• W2034340607 date "2010-12-01" @default.
• W2034340607 modified "2023-10-18" @default.
• W2034340607 title "Na⁺/H⁺exchanger-1: a link with atherogenesis?" @default.
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