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- W203434193 endingPage "434" @default.
- W203434193 startingPage "409" @default.
- W203434193 abstract "Presynaptic receptors for four families of neuropeptides will be discussed: opioids, neuropeptide Y, adrenocorticotropic hormone (ACTH), and orexins. Presynaptic receptors for the opioids (micro, delta, kappa, and ORL(1)) and neuropeptide Y (Y(2)) inhibit transmitter release from a variety of neurones, both in the peripheral and central nervous systems. These receptors, which were also identified in human tissue, are coupled to G(i/o) proteins and block voltage-dependent Ca(2+) channels, activate voltage-dependent K(+) channels, and/or interfere with the vesicle release machinery. Presynaptic receptors for ACTH (MC(2) receptors) have so far been identified almost exclusively in cardiovascular tissues from rabbits, where they facilitate noradrenaline release; they are coupled to G(s) protein and act via stimulation of adenylyl cyclase. Presynaptic receptors for orexins (most probably OX(2) receptors) have so far almost exclusively been identified in the rat and mouse brain, where they facilitate the release of glutamate and gamma-aminobutyric acid (GABA); they are most probably linked to G(q) and directly activate the vesicle release machinery or act via a transduction mechanism upstream of the release process. Agonists and antagonists at opioid receptors owe at least part of their therapeutic effects to actions on presynaptic receptors. Therapeutic drugs targeting neuropeptide Y and orexin receptors and presynaptic ACTH receptors so far are not available." @default.
- W203434193 created "2016-06-24" @default.
- W203434193 creator A5058546309 @default.
- W203434193 creator A5090924454 @default.
- W203434193 date "2008-01-01" @default.
- W203434193 modified "2023-09-23" @default.
- W203434193 title "Presynaptic Neuropeptide Receptors" @default.
- W203434193 cites W1241697 @default.
- W203434193 cites W1488521817 @default.
- W203434193 cites W1577236025 @default.
- W203434193 cites W1583982978 @default.
- W203434193 cites W1584764339 @default.
- W203434193 cites W1771226674 @default.
- W203434193 cites W1795823327 @default.
- W203434193 cites W1866229087 @default.
- W203434193 cites W1946662971 @default.
- W203434193 cites W1951056124 @default.
- W203434193 cites W1959892192 @default.
- W203434193 cites W1968683631 @default.
- W203434193 cites W1970734837 @default.
- W203434193 cites W1970809582 @default.
- W203434193 cites W1973370124 @default.
- W203434193 cites W1974053949 @default.
- W203434193 cites W1975282297 @default.
- W203434193 cites W1975653561 @default.
- W203434193 cites W1976575344 @default.
- W203434193 cites W1977527392 @default.
- W203434193 cites W1978996692 @default.
- W203434193 cites W1979051058 @default.
- W203434193 cites W1979188992 @default.
- W203434193 cites W1980194810 @default.
- W203434193 cites W1980858072 @default.
- W203434193 cites W1981428033 @default.
- W203434193 cites W1983298714 @default.
- W203434193 cites W1987781967 @default.
- W203434193 cites W1989492734 @default.
- W203434193 cites W1993486528 @default.
- W203434193 cites W1994079831 @default.
- W203434193 cites W1994162219 @default.
- W203434193 cites W1995382836 @default.
- W203434193 cites W1996178045 @default.
- W203434193 cites W1996848646 @default.
- W203434193 cites W1998165867 @default.
- W203434193 cites W2000549249 @default.
- W203434193 cites W2001204090 @default.
- W203434193 cites W2002705216 @default.
- W203434193 cites W2002931285 @default.
- W203434193 cites W2004401380 @default.
- W203434193 cites W2008682721 @default.
- W203434193 cites W2010051841 @default.
- W203434193 cites W2011085781 @default.
- W203434193 cites W2014438108 @default.
- W203434193 cites W2014599421 @default.
- W203434193 cites W2016658324 @default.
- W203434193 cites W2019476872 @default.
- W203434193 cites W2019935811 @default.
- W203434193 cites W2020674229 @default.
- W203434193 cites W2024876159 @default.
- W203434193 cites W2025414184 @default.
- W203434193 cites W2026210171 @default.
- W203434193 cites W2027749726 @default.
- W203434193 cites W2029872814 @default.
- W203434193 cites W2030962081 @default.
- W203434193 cites W2032831107 @default.
- W203434193 cites W203307584 @default.
- W203434193 cites W2035579388 @default.
- W203434193 cites W2036038964 @default.
- W203434193 cites W2036249690 @default.
- W203434193 cites W2036711514 @default.
- W203434193 cites W2036987610 @default.
- W203434193 cites W2037568583 @default.
- W203434193 cites W2040700968 @default.
- W203434193 cites W2045175240 @default.
- W203434193 cites W2048610961 @default.
- W203434193 cites W2051492392 @default.
- W203434193 cites W2052549510 @default.
- W203434193 cites W2053807193 @default.
- W203434193 cites W2061477327 @default.
- W203434193 cites W2063936869 @default.
- W203434193 cites W2064240507 @default.
- W203434193 cites W2064447108 @default.
- W203434193 cites W2065381788 @default.
- W203434193 cites W2072154498 @default.
- W203434193 cites W2073364642 @default.
- W203434193 cites W2074190656 @default.
- W203434193 cites W2074437114 @default.
- W203434193 cites W2077858461 @default.
- W203434193 cites W2079861171 @default.
- W203434193 cites W2080976200 @default.
- W203434193 cites W2089142635 @default.
- W203434193 cites W2090900093 @default.
- W203434193 cites W2091045478 @default.
- W203434193 cites W2092612400 @default.
- W203434193 cites W2092665486 @default.
- W203434193 cites W2093757254 @default.
- W203434193 cites W2095128347 @default.
- W203434193 cites W2095539700 @default.
- W203434193 cites W2099027338 @default.