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- W2034342273 endingPage "1163" @default.
- W2034342273 startingPage "1149" @default.
- W2034342273 abstract "As one of the largest and most functionally complex organs of the human body, the intestines are primarily responsible for the breakdown and uptake of macromolecules from the lumen and the subsequent excretion of waste from the body. However, the intestine is also an endocrine organ, regulating digestion, metabolism, and feeding behavior. Intricate neuronal, lymphatic, immune, and vascular systems are integrated into the intestine and are required for its digestive and endocrine functions. In addition, the gut houses an extensive population of microbes that play roles in digestion, global metabolism, barrier function, and host-parasite interactions. With such an extensive array of cell types working and performing in one essential organ, derivation of functional intestinal tissues from human pluripotent stem cells (PSCs) represents a significant challenge. Here we will discuss the intricate developmental processes and cell types that are required for assembly of this highly complex organ and how embryonic processes, particularly morphogenesis, have been harnessed to direct differentiation of PSCs into 3-dimensional human intestinal organoids (HIOs) in vitro. We will further describe current uses of HIOs in development and disease research and how additional tissue complexity might be engineered into HIOs for better functionality and disease modeling." @default.
- W2034342273 created "2016-06-24" @default.
- W2034342273 creator A5026300027 @default.
- W2034342273 creator A5037288031 @default.
- W2034342273 date "2015-03-19" @default.
- W2034342273 modified "2023-09-24" @default.
- W2034342273 title "Generating human intestinal tissues from pluripotent stem cells to study development and disease" @default.
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