Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034345819> ?p ?o ?g. }
- W2034345819 endingPage "940" @default.
- W2034345819 startingPage "929" @default.
- W2034345819 abstract "The exposure of rats to an enriched environment (EE) has several effects in common with the administration of antidepressants. However, there is still little information about the molecular underpinnings of these effects on rats subjected to experimental models of depression. The aim of this research was to evaluate the effects of EE on rats exposed to the learned helplessness paradigm (LH), a well-known model of the disease. We found that a 21 day exposure to EE reverts helplessness behavior to normal in LH animals. Inmunohistochemical labeling showed that this effect was accompanied by normalization of two structural proteins of hippocampal neurons to control values: the light neurofilament subunit (NFL) and the postsynaptic density 95 (PSD-95) protein, which were decreased in LH animals housed in standard cages. The decrease in the presynaptic protein synaptophysin (SYN) observed in LH animals remained unchanged after exposure to EE. There was no increase in neurogenesis as measured by quantification of double-labeled cells with 5-bromo-2'-deoxyuridine (BrdU) and the neuronal marker beta-tubulin class III. These results show that EE may have behavioral and synaptic effects on animals exposed to an experimental model of depression, and that such actions seem to be independent from neurogenesis." @default.
- W2034345819 created "2016-06-24" @default.
- W2034345819 creator A5000613916 @default.
- W2034345819 creator A5017785513 @default.
- W2034345819 creator A5033574879 @default.
- W2034345819 creator A5039707789 @default.
- W2034345819 creator A5056389253 @default.
- W2034345819 creator A5062928852 @default.
- W2034345819 creator A5071074785 @default.
- W2034345819 creator A5090612920 @default.
- W2034345819 date "2009-12-01" @default.
- W2034345819 modified "2023-10-07" @default.
- W2034345819 title "An enriched environment restores normal behavior while providing cytoskeletal restoration and synaptic changes in the hippocampus of rats exposed to an experimental model of depression" @default.
- W2034345819 cites W1487695731 @default.
- W2034345819 cites W1556473668 @default.
- W2034345819 cites W1800284117 @default.
- W2034345819 cites W1963940970 @default.
- W2034345819 cites W1967976287 @default.
- W2034345819 cites W1971966276 @default.
- W2034345819 cites W1977059675 @default.
- W2034345819 cites W1981957263 @default.
- W2034345819 cites W1982371864 @default.
- W2034345819 cites W1983706324 @default.
- W2034345819 cites W1991932902 @default.
- W2034345819 cites W1995975876 @default.
- W2034345819 cites W2000287799 @default.
- W2034345819 cites W2003983445 @default.
- W2034345819 cites W2004437604 @default.
- W2034345819 cites W2006129024 @default.
- W2034345819 cites W2008231906 @default.
- W2034345819 cites W2009021229 @default.
- W2034345819 cites W2011573205 @default.
- W2034345819 cites W2019000660 @default.
- W2034345819 cites W2022372660 @default.
- W2034345819 cites W2022705283 @default.
- W2034345819 cites W2022950473 @default.
- W2034345819 cites W2024989312 @default.
- W2034345819 cites W2026717174 @default.
- W2034345819 cites W2028616351 @default.
- W2034345819 cites W2029015906 @default.
- W2034345819 cites W2033968045 @default.
- W2034345819 cites W2037701234 @default.
- W2034345819 cites W2041156404 @default.
- W2034345819 cites W2044715983 @default.
- W2034345819 cites W2045905702 @default.
- W2034345819 cites W2047978369 @default.
- W2034345819 cites W2047980182 @default.
- W2034345819 cites W2052327461 @default.
- W2034345819 cites W2057704927 @default.
- W2034345819 cites W2058873342 @default.
- W2034345819 cites W2061929866 @default.
- W2034345819 cites W2063394935 @default.
- W2034345819 cites W2064148637 @default.
- W2034345819 cites W2065843454 @default.
- W2034345819 cites W2072673889 @default.
- W2034345819 cites W2074236564 @default.
- W2034345819 cites W2074764259 @default.
- W2034345819 cites W2076137498 @default.
- W2034345819 cites W2076555882 @default.
- W2034345819 cites W2079156156 @default.
- W2034345819 cites W2082305818 @default.
- W2034345819 cites W2083194463 @default.
- W2034345819 cites W2084850612 @default.
- W2034345819 cites W2086075794 @default.
- W2034345819 cites W2092245844 @default.
- W2034345819 cites W2096472685 @default.
- W2034345819 cites W2109163290 @default.
- W2034345819 cites W2111443630 @default.
- W2034345819 cites W2121651624 @default.
- W2034345819 cites W2124052066 @default.
- W2034345819 cites W2126395942 @default.
- W2034345819 cites W2133565799 @default.
- W2034345819 cites W2136487382 @default.
- W2034345819 cites W2140178312 @default.
- W2034345819 cites W2151330068 @default.
- W2034345819 cites W2151538478 @default.
- W2034345819 doi "https://doi.org/10.1016/j.neuroscience.2009.08.059" @default.
- W2034345819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19729049" @default.
- W2034345819 hasPublicationYear "2009" @default.
- W2034345819 type Work @default.
- W2034345819 sameAs 2034345819 @default.
- W2034345819 citedByCount "21" @default.
- W2034345819 countsByYear W20343458192012 @default.
- W2034345819 countsByYear W20343458192014 @default.
- W2034345819 countsByYear W20343458192015 @default.
- W2034345819 countsByYear W20343458192017 @default.
- W2034345819 countsByYear W20343458192019 @default.
- W2034345819 countsByYear W20343458192021 @default.
- W2034345819 countsByYear W20343458192023 @default.
- W2034345819 crossrefType "journal-article" @default.
- W2034345819 hasAuthorship W2034345819A5000613916 @default.
- W2034345819 hasAuthorship W2034345819A5017785513 @default.
- W2034345819 hasAuthorship W2034345819A5033574879 @default.
- W2034345819 hasAuthorship W2034345819A5039707789 @default.
- W2034345819 hasAuthorship W2034345819A5056389253 @default.
- W2034345819 hasAuthorship W2034345819A5062928852 @default.
- W2034345819 hasAuthorship W2034345819A5071074785 @default.
- W2034345819 hasAuthorship W2034345819A5090612920 @default.