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- W2034346151 abstract "The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE–EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE–EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim." @default.
- W2034346151 created "2016-06-24" @default.
- W2034346151 creator A5033696694 @default.
- W2034346151 creator A5047705697 @default.
- W2034346151 date "2009-12-01" @default.
- W2034346151 modified "2023-09-26" @default.
- W2034346151 title "MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma" @default.
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- W2034346151 doi "https://doi.org/10.1016/j.coph.2009.08.009" @default.
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