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• W2034346964 abstract "<h3>Background and importance</h3> Estimating glomerular filtration rate (GFR) in critically ill patients is challenging due to fluctuations in kidney function and creatinine production. Creatinine clearance computed from a 24-hour (CrCl_24h) urine collection cannot always be performed. Therefore, equations based on serum creatinine are commonly used to estimate GFR. However, it is still questionable which formula performs best in this setting. <h3>Aim and objectives</h3> We aimed to assess the performance of different serum creatinine-based equations to estimate GFR in critically ill patients. <h3>Material and methods</h3> Observational retrospective study conducted in four intensive care units of a tertiary hospital from January to September 2020, consecutive patients with a measured CrCl_24h were included. CrCl_24h was compared to the most commonly used GFR estimating equations: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Modification of Diet in Renal Disease (MDRD-4) and Cockcroft–Gault (CG). Pearson coefficients were estimated to evaluate the relationship between CrCl_24h and CKD-EPI, MDRD-4 or CG. Bland and Altman plots, bias and precision were performed to contrast CrCl_24h values with estimated GFR. Data were stratified into patients with CrCl_24h between 0 and 129 mL/min/1.73m² and patients with an augmented renal clearance (ARC) (GFR ≥130 mL/min/1.73m²). <h3>Results</h3> 261 patients were included in the study (60.2% male, with a mean±SD age of 62±15 years and a serum creatinine of 1.23±1.00 mg/dL). For the subgroup with GFR between 0 and 129 mL/min/1.73m², Pearson coefficients estimated for CKD-EPI, MDRD-4 and CG were 0.729, 0.637 and 0.680, respectively. Bland and Altman plots showed homogenous distribution for CKD-EPI and CG but were less homogenous for MDRD-4. No statistically significant differences were found between equations in terms of bias and precision. For the subgroup with GFR ≥130 mL/min/1.73m², Pearson coefficients estimated for CKD-EPI, MDRD-4 and CG were 0.312, 0.329 and 0.388, respectively. Bland and Altman plots showed homogenous distribution for CG and more heterogenous distribution for CKD-EPI and MDRD-4. Bias was statistically different between CKD-EPI and both CG and MDRD-4 (p=0.0032) but precision was not (Figure 1). <h3>Conclusion and relevance</h3> According to the data, no differences were found between formulas to estimate GFR for critically ill patients with a CrCl_24h between 0 and 129 mL/min/1.73m²; whereas for patients with ARC, CG and MDRD-4 seemed to be more appropriate for estimating GFR. <h3>References and/or acknowledgements</h3> <h3>Conflict of interest</h3> No conflict of interest" @default.
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• W2034346964 title "Hemifacial spasm: a prospective long-term follow up of 83 cases treated by microvascular decompression at two neurosurgical centres in the United Kingdom." @default.
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• W2034346964 doi "https://doi.org/10.1136/jnnp.60.1.72" @default.
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