FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034347152> ?p ?o ?g. }

• W2034347152 endingPage "44" @default.
• W2034347152 startingPage "32" @default.
• W2034347152 abstract "Background Mouse epidermal chronologic aging is closely associated with aberrant matrix (hyaluronan, HA)-size distribution/production and impaired keratinocyte proliferation/differentiation, leading to a marked thinning of the epidermis with functional consequence that causes a slower recovery of permeability barrier function. Objective The goal of this study is to demonstrate mechanism-based, corrective therapeutic strategies using topical applications of small HA (HAS) and/or large HA (HAL) [or a sequential small HA (HAS) and large HA(HAL) (HAs → HAL) treatment] as well as RhoGTPase signaling perturbation agents to regulate HA/CD44-mediated signaling, thereby restoring normal epidermal function, and permeability barrier homeostasis in aged mouse skin. Methods A number of biochemical, cell biological/molecular, pharmacological and physiological approaches were used to investigate matrix HA-CD44-mediated RhoGTPase signaling in regulating epidermal functions and skin aging. Results In this study we demonstrated that topical application of small HA (HAS) promotes keratinocyte proliferation and increases skin thickness, while it fails to upregulate keratinocyte differentiation or permeability barrier repair in aged mouse skin. In contrast, large HA (HAL) induces only minimal changes in keratinocyte proliferation and skin thickness, but restores keratinocyte differentiation and improves permeability barrier function in aged epidermis. Since neither HAS nor HAL corrects these epidermal defects in aged CD44 knock-out mice, CD44 likely mediates HA-associated epidermal functions in aged mouse skin. Finally, blockade of Rho-kinase activity with Y27632 or protein kinase-Nγ activity with Ro31-8220 significantly decreased the HA (HAS or HAL)-mediated changes in epidermal function in aged mouse skin. Conclusion The results of our study show first that HA application of different sizes regulates epidermal proliferation, differentiation and barrier function in aged mouse skin. Second, manipulation of matrix (HA) interaction with CD44 and RhoGTPase signaling could provide further novel therapeutic approaches that could be targeted for the treatment of various aging-related skin disorders." @default.
• W2034347152 created "2016-06-24" @default.
• W2034347152 creator A5024154572 @default.
• W2034347152 creator A5050608918 @default.
• W2034347152 creator A5057037392 @default.
• W2034347152 creator A5062047914 @default.
• W2034347152 creator A5069496915 @default.
• W2034347152 creator A5082650655 @default.
• W2034347152 date "2013-10-01" @default.
• W2034347152 modified "2023-09-25" @default.
• W2034347152 title "Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction" @default.
• W2034347152 cites W1953366620 @default.
• W2034347152 cites W1963857212 @default.
• W2034347152 cites W1966422114 @default.
• W2034347152 cites W1969499061 @default.
• W2034347152 cites W1969564302 @default.
• W2034347152 cites W1981971440 @default.
• W2034347152 cites W1987893498 @default.
• W2034347152 cites W1990052258 @default.
• W2034347152 cites W1991882329 @default.
• W2034347152 cites W1997073923 @default.
• W2034347152 cites W1999304676 @default.
• W2034347152 cites W2001953889 @default.
• W2034347152 cites W2007350878 @default.
• W2034347152 cites W2014226393 @default.
• W2034347152 cites W2017814558 @default.
• W2034347152 cites W2019826954 @default.
• W2034347152 cites W2024016078 @default.
• W2034347152 cites W2029188106 @default.
• W2034347152 cites W2032295238 @default.
• W2034347152 cites W2033403956 @default.
• W2034347152 cites W2036435176 @default.
• W2034347152 cites W2042171099 @default.
• W2034347152 cites W2043411450 @default.
• W2034347152 cites W2047533360 @default.
• W2034347152 cites W2049508142 @default.
• W2034347152 cites W2049609559 @default.
• W2034347152 cites W2050333516 @default.
• W2034347152 cites W2052526013 @default.
• W2034347152 cites W2053566915 @default.
• W2034347152 cites W2054541267 @default.
• W2034347152 cites W2061626698 @default.
• W2034347152 cites W2067576948 @default.
• W2034347152 cites W2069207562 @default.
• W2034347152 cites W2074024610 @default.
• W2034347152 cites W2080844302 @default.
• W2034347152 cites W2088603460 @default.
• W2034347152 cites W2096791952 @default.
• W2034347152 cites W2103427562 @default.
• W2034347152 cites W2107928168 @default.
• W2034347152 cites W2109352233 @default.
• W2034347152 cites W2116506777 @default.
• W2034347152 cites W2119486893 @default.
• W2034347152 cites W2124003492 @default.
• W2034347152 cites W2127466034 @default.
• W2034347152 cites W2131977612 @default.
• W2034347152 cites W2144032514 @default.
• W2034347152 cites W2145261791 @default.
• W2034347152 cites W2153352377 @default.
• W2034347152 cites W2158581886 @default.
• W2034347152 cites W2169019804 @default.
• W2034347152 cites W2324113232 @default.
• W2034347152 cites W2573540928 @default.
• W2034347152 cites W4244406676 @default.
• W2034347152 cites W4253779214 @default.
• W2034347152 doi "https://doi.org/10.1016/j.jdermsci.2013.05.003" @default.
• W2034347152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3775883" @default.
• W2034347152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23790635" @default.
• W2034347152 hasPublicationYear "2013" @default.
• W2034347152 type Work @default.
• W2034347152 sameAs 2034347152 @default.
• W2034347152 citedByCount "56" @default.
• W2034347152 countsByYear W20343471522014 @default.
• W2034347152 countsByYear W20343471522015 @default.
• W2034347152 countsByYear W20343471522016 @default.
• W2034347152 countsByYear W20343471522017 @default.
• W2034347152 countsByYear W20343471522018 @default.
• W2034347152 countsByYear W20343471522019 @default.
• W2034347152 countsByYear W20343471522020 @default.
• W2034347152 countsByYear W20343471522021 @default.
• W2034347152 countsByYear W20343471522022 @default.
• W2034347152 countsByYear W20343471522023 @default.
• W2034347152 crossrefType "journal-article" @default.
• W2034347152 hasAuthorship W2034347152A5024154572 @default.
• W2034347152 hasAuthorship W2034347152A5050608918 @default.
• W2034347152 hasAuthorship W2034347152A5057037392 @default.
• W2034347152 hasAuthorship W2034347152A5062047914 @default.
• W2034347152 hasAuthorship W2034347152A5069496915 @default.
• W2034347152 hasAuthorship W2034347152A5082650655 @default.
• W2034347152 hasBestOaLocation W20343471522 @default.
• W2034347152 hasConcept C105702510 @default.
• W2034347152 hasConcept C1491633281 @default.
• W2034347152 hasConcept C185592680 @default.
• W2034347152 hasConcept C2776458125 @default.
• W2034347152 hasConcept C2777074287 @default.
• W2034347152 hasConcept C2780932548 @default.
• W2034347152 hasConcept C502942594 @default.
• W2034347152 hasConcept C51911345 @default.

• next