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- W2034347795 abstract "Abstract The impact of ionizing radiation on a globular protein (porcine somatotropin, pST) in the solid state was studied using rate of dissolution, high-performance liquid chromatography, and Electron spin resonance (ESR) in the presence of different additives. o -Vanillin stabilized pST against irradiation-induced degradation whereas effects of trolox and isopropyl alcohol were less significant. Stabilization effect of o -vanillin has been related to the energy transfer from pST molecules to the additive which was facilitated by formation of covalent bonds between o -vanillin and pST molecules. Anticorrelation between the level of free radicals and chemical degradation (i.e. degradation increased with decrease in a free radical level) was observed in the presence of o -vanillin." @default.
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- W2034347795 date "2003-03-01" @default.
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- W2034347795 title "Protection of a protein against irradiation-induced degradation by additives in the solid state" @default.
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- W2034347795 doi "https://doi.org/10.1016/s0969-806x(02)00287-6" @default.
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