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- W2034348189 abstract "The difference in mean costs between a placebo and a drug treated group is used for the pharmacoeconomic evaluation of a new drug. The distribution of costs without treatment (null hypothesis) is determined through hospital records. The sampling properties are established by simulation. The results of the simulation allow determination of a break point of differences corresponding to a given level of significance. For power determination, using this break point, clinical hypotheses are used to generate the distribution of costs under treatment (alternative hypothesis)." @default.
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- W2034348189 date "1997-02-01" @default.
- W2034348189 modified "2023-09-25" @default.
- W2034348189 title "The difference in mean costs as a pharmacoeconomic outcome variable: Power considerations" @default.
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- W2034348189 doi "https://doi.org/10.1016/s0197-2456(95)00258-8" @default.
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